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Cat. No.: HY-W1130452

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Lipid C16-C

Lipid C16-C is an ionizable cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for mRNA delivery. Lipid C16-C mediates ApoE-independent macropinocytosis-based mRNA delivery to macrophages, with endosomal acidification enabling endosomal escape and release of mRNA cargo into the cytosol.

For research use only. We do not sell to patients.

CAS No.: 2639634-86-7
Formula: C₉₈H₂₀₁N₅O₉
Molecular Weight:1593.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Lipid C16-C Chemical Structure

CAS No.: 2639634-86-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Lipid C16-C (250-500 ng mRNA per 50k cells; 24 h) enables potent mRNA delivery to PMA-differentiated human THP-1 macrophages, with the optimized B15 formulation showing 13-fold enhanced delivery relative to the initial formulation^[1].
The B15 formulation with Lipid C16-C (up to 1500 ng mRNA per 50k cells; 24 h) enables robust mRNA delivery to both GMCSF- and MCSF-derived primary human macrophages, with differential transfection profiles between the two models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The Lipid C16-C-containing B15 formulation (5 µg luciferase mRNA per mouse; i.v.; single dose) exhibits ApoE-independent extrahepatic tropism with significant spleen targeting in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2639634-86-7
Molecular Weight 1593.67
Formula C₉₈H₂₀₁N₅O₉
SMILES

OC(CCCCCCCCCCCCCC)CN(CCN1CCN(CCOCCOCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)CC1)CCOCCOCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alvin J. Mukalel, et al. Bioinspired Oxidized mRNA Lipid Nanoparticles for Ex Vivo Engineering of Chimeric Antigen Receptor Macrophages Targeting Solid Tumors. bioRxiv. June 11, 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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