2. Metabolic Enzyme/Protease
  3. Liposome
  4. Lipid C16-C

Lipid C16-C is an ionizable cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for mRNA delivery. Lipid C16-C mediates ApoE-independent macropinocytosis-based mRNA delivery to macrophages, with endosomal acidification enabling endosomal escape and release of mRNA cargo into the cytosol.

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Lipid C16-C

Lipid C16-C Chemical Structure

CAS No. : 2639634-86-7

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Lipid C16-C Related Antibodies

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Description

Lipid C16-C is an ionizable cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for mRNA delivery. Lipid C16-C mediates ApoE-independent macropinocytosis-based mRNA delivery to macrophages, with endosomal acidification enabling endosomal escape and release of mRNA cargo into the cytosol[1].

In Vitro

Lipid C16-C (250-500 ng mRNA per 50k cells; 24 h) enables potent mRNA delivery to PMA-differentiated human THP-1 macrophages, with the optimized B15 formulation showing 13-fold enhanced delivery relative to the initial formulation[1].
The B15 formulation with Lipid C16-C (up to 1500 ng mRNA per 50k cells; 24 h) enables robust mRNA delivery to both GMCSF- and MCSF-derived primary human macrophages, with differential transfection profiles between the two models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lipid C16-C Related Antibodies
In Vivo

The Lipid C16-C-containing B15 formulation (5 µg luciferase mRNA per mouse; i.v.; single dose) exhibits ApoE-independent extrahepatic tropism with significant spleen targeting in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1593.67

Formula

C98H201N5O9
CAS No.
SMILES

OC(CCCCCCCCCCCCCC)CN(CCN1CCN(CCOCCOCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)CC1)CCOCCOCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lipid C16-C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipid C16-C2639634-86-7Liposomehuman THP-1 macrophagesendosomal acidificationspleensolid tumorsSKOV3 ovarian cancer cellsApoEmacropinocytosismacrophagesovarian cancer cellsprimary human HER2-CAR macrophagesInhibitorinhibitorinhibit

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