2639634-86-7
2639634-86-7
Chemical Structure
Lipid C16-C
- CAS No.: 2639634-86-7
- Formula:C98H201N5O9
- Molecular Weight:1593.67
InChIKey: AFXLHIXDLDFTAT-UHFFFAOYSA-N
SMILES: OC(CCCCCCCCCCCCCC)CN(CCN1CCN(CCOCCOCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)CC1)CCOCCOCCN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC
Biological Activity: Lipid C16-C is an ionizable cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for mRNA delivery. Lipid C16-C mediates ApoE-independent macropinocytosis-based mRNA delivery to macrophages, with endosomal acidification enabling endosomal escape and release of mRNA cargo into the cytosol[1].
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Lipid C16-C | Lipid C16-C is an ionizable cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for mRNA delivery. Lipid C16-C mediates ApoE-independent macropinocytosis-based mRNA delivery to macrophages, with endosomal acidification enabling endosomal escape and release of mRNA cargo into the cytosol. | |||||||||||||||||||||
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References
Keywords
