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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
modest activity
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "modest activity" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-18010
CAS No.: 330786-25-9
Research Areas:
PCI 29732 is a potent, orally active, reversible BTK inhibitor with Ki app values of 8.2, 4.6, and 2.5 nM for BTK, Lck and Lyn, respectively. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase. PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 .
2
2 Cited Publications
Research Areas:
LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC50 of 3.3 nM and a Ki of 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 shows antinociceptive activity. LP-935509 can be used for neuropathic pain and SARS-CoV-2 research .
1
1 Cited Publications
Cat. No.: HY-B1618S
CAS No.: 1271728-07-4
Target:
Research Areas:
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration .
Synonyms: SBP-101
Target:
Research Areas:
Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers .
Cat. No.: HY-B1737
CAS No.: 75444-65-4
Synonyms: R 47465
Target:
Research Areas:
Pirenperone (R 47465) is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity .
Synonyms: 3,8-Quinolinediol
Target:
Cat. No.: HY-B1618S1
CAS No.: 2243253-91-8
Synonyms: 17-Deoxycortisol-d4; 11β,21-Dihydroxyprogesterone-d4; Kendall's compound B-d4
Cat. No.: HY-N3211
CAS No.: 80510-09-4
Synonyms: cis-N-(4-Hydroxyphenethyl) ferulamide; cis-N-Feruloyltyramine
Category:
Annona cherimola Mill. Phenols Polyphenols Plants Annonaceae
Target:
Target:
Research Areas:
OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity .
Cat. No.: HY-113876
CAS No.: 10130-23-1
2-Methyl-3-phenylquinoxaline (compound 38) is a potent platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) inhibitor with modest inhibitory activity against PDGFR kinase in intact cells (IC50 greater than 100 μM) .
Cat. No.: HY-132822A
CAS No.: 259657-09-5
Synonyms: SBP-101 hydrochloride
Target:
Research Areas:
Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers .
Cat. No.: HY-117220
CAS No.: 1173040-34-0
Target:
Cat. No.: HY-123228
CAS No.: 749269-77-0
Target:
Research Areas:
CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (−22.2±4.8% at 100 μM) .
Cat. No.: HY-N14111
CAS No.: 1246172-08-6
Category:
Cat. No.: HY-N14112
CAS No.: 274684-11-6
Category:
Cat. No.: HY-P11128
CAS No.: 1427516-68-4
Cat. No.: HY-122300B
CAS No.: 76496-68-9
Synonyms: Levoprotiline
Target:
Research Areas:
R-(-)-Oxaprotiline (Levoprotiline) is an antidepressant with anticholinergic and sympathostimulatory activities. R-(-)-Oxaprotiline exhibits different abilities to block norepinephrine uptake and anticholinergic activity compared to its enantiomer C 49802 B-Ba. R-(-)-Oxaprotiline in human studies shows physiological effects consistent with those in animals. Administration of R-(-)-Oxaprotiline results in a modest increase in heart rate and arterial blood pressure. Salivation is inhibited with R-(-)-Oxaprotiline, consistent with its anticholinergic properties. R-(-)-Oxaprotiline has similar effects to the established antidepressant compound Levoprotiline and has a shorter onset of action .
Cat. No.: HY-122038
CAS No.: 849723-20-2
NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
