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NU-8165

NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines.

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  • CAS No.: 849723-20-2
  • Formula: C24H22ClNO3
  • Molecular Weight:407.89
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • NU-8165 Chemical Structure
    NU-8165 Chemical Structure
CAS No.: 849723-20-2
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    NU-8165 Chemical Structure
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  • NU-8165