849723-20-2
Chemical Structure
NU-8165
- CAS No.: 849723-20-2
- Formula:C24H22ClNO3
- Molecular Weight:407.89
IUPAC Name: 2-benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)isoindolin-1-one
InChIKey: RDFQXKACQGFINF-UHFFFAOYSA-N
SMILES: O=C1N(CC2=CC=CC=C2)C(OCCCO)(C3=CC=C(Cl)C=C3)C4=C1C=CC=C4
Biological Activity: NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines[1].
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NU-8165 | NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines. | |||||||||||||||||||||
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Keywords
