Corticosterone-d8
Based on 1 publication(s) in Google Scholar
Corticosterone-d8 is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 1271728-07-4
- Formula: C21H22D8O4
- Molecular Weight:354.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Corticosterone-d8
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1271728-07-4
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Unlabeled Cas 50-22-6
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Appearance Solid
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Molecular Weight 354.51
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Formula C21H22D8O4
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](CC([2H])([2H])C1=C([2H])C(C([2H])([2H])C2)=O)([H])[C@@]4([H])[C@](C[C@@H]3O)([C@@](CC4)([2H])C(C([2H])([2H])O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : ≥ 100 mg/mL (282.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 14.29 mg/mL (40.31 mM; Need ultrasonic)
H2O : 0.67 mg/mL (1.89 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Gasser PJ, et al. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organiccation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-8766. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / Ethanol / DMSO | 1 mM | 2.8208 mL | 14.1040 mL | 28.2079 mL | 70.5199 mL |
| Ethanol / DMSO | 5 mM | 0.5642 mL | 2.8208 mL | 5.6416 mL | 14.1040 mL |
| 10 mM | 0.2821 mL | 1.4104 mL | 2.8208 mL | 7.0520 mL | |
| 15 mM | 0.1881 mL | 0.9403 mL | 1.8805 mL | 4.7013 mL | |
| 20 mM | 0.1410 mL | 0.7052 mL | 1.4104 mL | 3.5260 mL | |
| 25 mM | 0.1128 mL | 0.5642 mL | 1.1283 mL | 2.8208 mL | |
| 30 mM | 0.0940 mL | 0.4701 mL | 0.9403 mL | 2.3507 mL | |
| 40 mM | 0.0705 mL | 0.3526 mL | 0.7052 mL | 1.7630 mL | |
| DMSO | 50 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.4104 mL |
| 60 mM | 0.0470 mL | 0.2351 mL | 0.4701 mL | 1.1753 mL | |
| 80 mM | 0.0353 mL | 0.1763 mL | 0.3526 mL | 0.8815 mL | |
| 100 mM | 0.0282 mL | 0.1410 mL | 0.2821 mL | 0.7052 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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