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  3. OXFBD04

OXFBD04 

Cat. No.: HY-135236 Purity: 99.19%
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OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity.

For research use only. We do not sell to patients.

OXFBD04 Chemical Structure

OXFBD04 Chemical Structure

CAS No. : 2231747-03-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 595 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity[1].

IC50 & Target[1]

BRD4

166 nM (IC50)

In Vitro

OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth[1].
OXFBD04 (10 µM; for 10, 24, or 48 hours) induces MYC suppression in MCF7 breast cancer cells[1].

Cell Viability Assay[1]

Cell Line: A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 hours
Result: Inhibited cancer cell lines growth.
In Vivo

OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t1/2=388 min). OXFBD04 has CLint of 3.57 µL/min/mg[1].

Molecular Weight

296.32

Formula

C₁₇H₁₆N₂O₃

CAS No.

2231747-03-6

SMILES

OC(C1=CC(O)=CC(C2=C(C)ON=C2C)=C1)C3=CC=CN=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (843.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3747 mL 16.8736 mL 33.7473 mL
5 mM 0.6749 mL 3.3747 mL 6.7495 mL
10 mM 0.3375 mL 1.6874 mL 3.3747 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OXFBD04OXFBD 04OXFBD-04Epigenetic Reader DomainBETbromodomainligandCREBBPanti-cancerrenalcolonbreastmetabolicstabilityInhibitorinhibitorinhibit

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OXFBD04
Cat. No.:
HY-135236
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