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OXFBD04 

Cat. No.: HY-135236
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OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity.

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OXFBD04 Chemical Structure

OXFBD04 Chemical Structure

CAS No. : 2231747-03-6

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Description

OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity[1].

IC50 & Target

BRD4

166 nM (IC50)

In Vitro

OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth[1].
OXFBD04 (10 µM; for 10, 24, or 48 hours) induces MYC suppression in MCF7 breast cancer cells[1].

Cell Viability Assay[1]

Cell Line: A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 hours
Result: Inhibited cancer cell lines growth.
In Vivo

OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t1/2=388 min). OXFBD04 has CLint of 3.57 µL/min/mg[1].

Molecular Weight

296.32

Formula

C₁₇H₁₆N₂O₃

CAS No.

2231747-03-6

SMILES

OC(C1=CC(O)=CC(C2=C(C)ON=C2C)=C1)C3=CC=CN=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OXFBD04OXFBD 04OXFBD-04Epigenetic Reader DomainBETbromodomainligandCREBBPanti-cancerrenalcolonbreastmetabolicstabilityInhibitorinhibitorinhibit

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