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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
neuronal PC12 cells
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "neuronal PC12 cells" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-159059
Purity: 41.20%
Category:
Alkaloids Piperidine Alkaloids Ranunculaceae Other Diseases Plants Disease Research Fields
Target:
Cat. No.: HY-N11229
CAS No.: 22020-28-6
Synonyms: Caffeic acid butyl ester
Cat. No.: HY-N5021
CAS No.: 184840-84-4
Synonyms: AHSYB
Category:
Quinones Carthamus tinctorius L. Simple Phenylpropanols Phenols Polyphenols Benzene Quinones Phenylpropanoids Plants Compositae
Target:
Cat. No.: HY-P10998
CAS No.: 270919-17-0
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Cat. No.: HY-125172
CAS No.: 300670-16-0
Synonyms: Polyglutamine Aggregation inhibitor III
Target:
Research Areas:
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Cat. No.: HY-P11082
CAS No.: 126675-52-3
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Cat. No.: HY-P5754B
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Research Areas:
Cat. No.: HY-NP144
CAS No.: 93928-24-6
Category:
Cardiovascular Disease Flavones Plants other families Flavonoids Monophenols Phenols Disease Research Fields Docyniopsis tschonoski Cancer
Target:
Synonyms: (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)
Category:
Cat. No.: HY-17638A
CAS No.: 1169392-27-1
Synonyms: DSP-3235 (sebacate); KGA-3235 (sebacate); GSK-1614235 (sebacate)
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Research Areas:
Mizagliflozin sebacate (DSP-3235 sebacate) is a sodium-glucose cotransporter inhibitor with activity in improving vascular cognitive impairment caused by small vessel disease. Mizagliflozin sebacate improves blood flow and reverses vascular cognitive impairment by inhibiting neuronal SGLT1 activity. Mizagliflozin sebacate also showed the ability to increase the survival rate of IL-1β-treated PC12HS cells. Mizagliflozin sebacate promotes improvements in spatial learning and memory caused by small vessel disease in mouse models .
Cat. No.: HY-N20640
CAS No.: 129102-89-2
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Cat. No.: HY-D3226
CAS No.: 2417345-13-0
Cat. No.: HY-N19681
CAS No.: 1083198-53-1
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Cat. No.: HY-179037
CAS No.: 1120333-38-1
Research Areas:
NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases .
Category:
Cat. No.: HY-182068
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Research Areas:
NFI23 is a blood-brain barrier-penetrant GluN2B-NMDAR inhibitor, with an IC50 of 1.31 μM and a Ki of 5.98 nM against GluN2B-NMDAR. NFI23 reduces NMDA-induced Ca 2+ influx and ROS production, maintains mitochondrial membrane potential, inhibits neuronal apoptosis, and restores the expression of p-ERK1/2. NFI23 exerts neuroprotective effects against NMDA-induced cytotoxicity and in the rat middle cerebral artery occlusion (MCAO) model. NFI23 can be used for the research of ischemic stroke .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
