NecroX-2
NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases.
For research use only. We do not sell to patients.
- CAS No.: 1120333-38-1
- Formula: C25H32N4O4S2
- Molecular Weight:516.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NecroX-2 displays in vitro antioxidant activity with an IC50 of 17 μM in the DPPH radical-scavenging assay, and exhibits in vitro peroxynitrite scavenging activity with an IC50 of 0.9 μM[1].
NecroX-2 (0.4-10 μM; 2 h) inhibits copper ion-induced LDL oxidation[1].
NecroX-2 (2 h) potently inhibits t-BHP-induced mitochondrial ROS/RNS generation in H9C2 cells with an IC25 < 0.1 μM[1].
NecroX-2 (0.1-10 μM; 30 min pretreat) provides dose-dependent cytoprotection against t-BHP-induced cell death in H9C2 cells[1].
NecroX-2 (0.063-1.0 μM; 30 min pretreat) protects primary rat hepatocytes from Doxorubicin-induced cell death in a dose-dependent manner, with an IC50 of 0.12 μM [1].
NecroX-2 (0.3 μM; 30 min) suppresses caspase-independent necrosis in Cd-exposed SH-SY5Y and PC12 neuronal cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H9C2 cells
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Concentration:0.1, 1, 10 μM
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Incubation Time:30 min
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Result:Showed a dose-dependent cytoprotective effect against t-BHP-induced cell death, as measured by LDH assay.
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Cell Line:primary rat hepatocytes
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Concentration:0.063, 0.125, 0.25, 0.5, 1.0 μM
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Incubation Time:30 min pretreat
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Result:Displayed a dose-dependent cytoprotective effect against Doxorubicin-induced cell death at concentrations from 0.063 to 1.0 μM, with an IC50 of 0.12 μM, as measured by WST-1 assay.
Chemical Information
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CAS No. 1120333-38-1
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Molecular Weight 516.68
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Formula C25H32N4O4S2
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SMILES
O=S(N1CCC(CC1)NC2=CC(CN3CCS(=O)(CC3)=O)=CC4=C2NC(C5=CC=CC=C5)=C4)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kim HJ, et al. NecroX as a novel class of mitochondrial reactive oxygen species and ONOO⁻ scavenger. Arch Pharm Res. 2010;33(11):1813-1823. [Content Brief]
[2]. Wang B, et al. BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells. Toxicol Sci. 2014;140(2):393-402. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NecroX-2 Related Classifications
HY-179037 Related Classifications
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