NecroX-2 

NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases^[1][2].

NecroX-2 displays in vitro antioxidant activity with an IC₅₀ of 17 μM in the DPPH radical-scavenging assay, and exhibits in vitro peroxynitrite scavenging activity with an IC₅₀ of 0.9 μM^[1].
NecroX-2 (0.4-10 μM; 2 h) inhibits copper ion-induced LDL oxidation^[1].
NecroX-2 (2 h) potently inhibits t-BHP-induced mitochondrial ROS/RNS generation in H9C2 cells with an IC₂₅ < 0.1 μM^[1].
NecroX-2 (0.1-10 μM; 30 min pretreat) provides dose-dependent cytoprotection against t-BHP-induced cell death in H9C2 cells^[1].
NecroX-2 (0.063-1.0 μM; 30 min pretreat) protects primary rat hepatocytes from Doxorubicin-induced cell death in a dose-dependent manner, with an IC₅₀ of 0.12 μM ^[1].
NecroX-2 (0.3 μM; 30 min) suppresses caspase-independent necrosis in Cd-exposed SH-SY5Y and PC12 neuronal cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

516.68

C₂₅H₃₂N₄O₄S₂

1120333-38-1

O=S(N1CCC(CC1)NC2=CC(CN3CCS(=O)(CC3)=O)=CC4=C2NC(C5=CC=CC=C5)=C4)(C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kim HJ, et al. NecroX as a novel class of mitochondrial reactive oxygen species and ONOO⁻ scavenger. Arch Pharm Res. 2010;33(11):1813-1823.  [Content Brief]

  [2]. Wang B, et al. BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells. Toxicol Sci. 2014;140(2):393-402.  [Content Brief]