Butyl caffeate (Synonyms: Caffeic acid butyl ester)

Cat. No.: HY-N11229 Purity: 98.15%: Data Sheet
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Butyl caffeate (Caffeic acid butyl ester) is a caffeic acid derivative with antioxidant activity and lipophilicity (DPPH IC₅₀ = 14.1 μM). Butyl caffeate protects neuronal PC12 cells against oxidative stress. Butyl caffeate can be used for oxidative stress related and neurodegenerative diseases research.

For research use only. We do not sell to patients.

Butyl caffeate Chemical Structure

CAS No. : 22020-28-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.51 μM Compound: 2e	Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay Cytotoxicity against human A549 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
BeWo	IC₅₀	5.42 μM Compound: I-7	Antitumor activity against human Bewo cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human Bewo cells assessed as inhibition of cell growth by MTT assay	[PMID: 25160837]
Calu-1	IC₅₀	11.7 μM Compound: 2e	Cytotoxicity against human Calu1 cells after 72 hrs by alamar blue assay Cytotoxicity against human Calu1 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
HL-60	IC₅₀	7.54 μM Compound: I-7	Antitumor activity against human HL60 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human HL60 cells assessed as inhibition of cell growth by MTT assay	[PMID: 25160837]
HOP-62	IC₅₀	5.59 μM Compound: 2e	Cytotoxicity against human HOP62 cells after 72 hrs by alamar blue assay Cytotoxicity against human HOP62 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
HeLa	IC₅₀	0.59 μM Compound: 2e	Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay	[PMID: 22954735]
HeLa	IC₅₀	40.8 μM Compound: I-7	Antitumor activity against human HeLa cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human HeLa cells assessed as inhibition of cell growth by MTT assay	[PMID: 25160837]
HepG2	IC₅₀	> 100 μM Compound: I-7	Antitumor activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 25160837]
LNCaP	IC₅₀	45.4 μM Compound: 7	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs by WST-1 assay Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs by WST-1 assay	[PMID: 24080105]
LOX IMVI	IC₅₀	9.54 μM Compound: 2e	Cytotoxicity against human LOXIMVI cells after 72 hrs by alamar blue assay Cytotoxicity against human LOXIMVI cells after 72 hrs by alamar blue assay	[PMID: 22954735]
M14	IC₅₀	11.1 μM Compound: 2e	Cytotoxicity against human M14 cells after 72 hrs by alamar blue assay Cytotoxicity against human M14 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
NCI-H1299	IC₅₀	5.81 μM Compound: 2e	Cytotoxicity against human NCI-H1299 cells after 72 hrs by alamar blue assay Cytotoxicity against human NCI-H1299 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
NCI-H157	IC₅₀	2.62 μM Compound: 2e	Cytotoxicity against human NCI-H157 cells after 72 hrs by alamar blue assay Cytotoxicity against human NCI-H157 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
NCI-H1792	IC₅₀	5.75 μM Compound: 2e	Cytotoxicity against human NCI-H1792 cells after 72 hrs by alamar blue assay Cytotoxicity against human NCI-H1792 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
NCI-H460	IC₅₀	5.62 μM Compound: 2e	Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay	[PMID: 22954735]
RAW264.7	EC₅₀	0.24 μM Compound: 5, butyl caffeate	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay	[PMID: 18667320]
RAW264.7	EC₅₀	7.419 μM Compound: 5, butyl caffeate	Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay	[PMID: 18667320]
SGC-7901	IC₅₀	> 100 μM Compound: I-7	Antitumor activity against human SGC7901 cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human SGC7901 cells assessed as inhibition of cell growth by MTT assay	[PMID: 25160837]
SiHa	IC₅₀	40.97 μM Compound: I-7	Antitumor activity against human SiHa cells assessed as inhibition of cell growth by MTT assay Antitumor activity against human SiHa cells assessed as inhibition of cell growth by MTT assay	[PMID: 25160837]
WISH	IC₅₀	~ 3 μM Compound: 29	In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined	[PMID: 14684314]

Molecular Weight

236.26

Formula

C₁₃H₁₆O₄

CAS No.

22020-28-6

Appearance

Solid

SMILES

O=C(/C=C/C1=CC=C(C(O)=C1)O)OCCCC

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Purity: 98.15%

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Data Sheet (263 KB) SDS (252 KB)

COA (243 KB) HNMR (253 KB) RP-HPLC (248 KB)

Handling Instructions (2659 KB)

References

[1]. Garrido J, et al. Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress. Biochimie. 2012 Apr;94(4):961-7. [Content Brief]

Butyl caffeate Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butyl caffeate22020-28-6Caffeic acid butyl esterDrug DerivativeDrug derivativeneuronal PC12 cellscaffeic acidantioxidantlipophilicityneurodegenerative diseasesInhibitorinhibitorinhibit

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Butyl caffeate (Synonyms: Caffeic acid butyl ester)

Butyl caffeate Related Antibodies

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Butyl caffeate Related Classifications

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