Mizagliflozin (sebacate)
Based on 5 publication(s) in Google Scholar
Mizagliflozin sebacate (DSP-3235 sebacate) is a sodium-glucose cotransporter inhibitor with activity in improving vascular cognitive impairment caused by small vessel disease. Mizagliflozin sebacate improves blood flow and reverses vascular cognitive impairment by inhibiting neuronal SGLT1 activity. Mizagliflozin sebacate also showed the ability to increase the survival rate of IL-1β-treated PC12HS cells. Mizagliflozin sebacate promotes improvements in spatial learning and memory caused by small vessel disease in mouse models.
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- No. CAS: 1169392-27-1
- Fòrmula: C28H44N4O8.1/2C10H18O4
- Peso molecular:1331.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Mizagliflozin (sebacate)
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 1169392-27-1
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Peso molecular 1331.59
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Fòrmula C28H44N4O8.1/2C10H18O4
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SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=NNC(C(C)C)=C2CC3=C(C=C(C=C3)OCCCNCC(C)(C)C(N)=O)C.OC(CCCCCCCCC(O)=O)=O.[0.5]
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Synonyms
DSP-3235 (sebacate); KGA-3235 (sebacate); GSK-1614235 (sebacate)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Nature
2025 Aug;644(8078):1069-1077. PMID: 40634617 -
Nat Biomed Eng
Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. [Abstract]2022 Jul;6(7):867-881. PMID: 35798834 -
Basic Res Cardiol
SGLT1 contributes to glucose-mediated exacerbation of ischemia-reperfusion injury in ex vivo rat heart. [Abstract]2024 Oct;119(5):733-749. PMID: 39088085 -
RSC Adv
Synthesis, radiolabeling, and biological evaluation of methyl 6-deoxy-6-[18F]fluoro-4-thio-α-d-maltotrioside as a positron emission tomography bacterial imaging agent. [Abstract]2025 Mar 21;15(11):8809-8829. PMID: 40124918 -
Pureza y Documentación
Referencias
[1]. Inoue T, et al. Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. Eur J Pharmacol. 2017 Jul 5;806:25-31. [Content Brief]
[2]. Mizagliflozin, a selective SGLT1 inhibitor, improves vascular cognitive impairment in a mouse model of small vessel disease [Content Brief]
[3]. Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mizagliflozin (sebacate) Related Classifications
HY-17638A Related Classifications
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