1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Mizagliflozin

Mizagliflozin (Synonyms: DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base)

Cat. No.: HY-17638
Handling Instructions

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation.

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Mizagliflozin Chemical Structure

Mizagliflozin Chemical Structure

CAS No. : 666843-10-3

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Description

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation[1].

IC50 & Target

Ki: 27 nM (hSGLT1), 8170 nM (hSGLT2)[1]

In Vivo

Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect[1].
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)[2]

Animal Model: Male Wistar rats (rat model of low-fiber-diet-induced constipation)[1]
Dosage: 3, 10, 30 mg/kg
Administration: Oral
Result: Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation.
Molecular Weight

564.67

Formula

C₂₈H₄₄N₄O₈

CAS No.

666843-10-3

SMILES

O=C(N)C(C)(C)CNCCCOC1=CC=C(CC2=C(C(C)C)NN=C2O[[email protected]]3[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O3)O)O)O)C(C)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MizagliflozinDSP-3235KGA-3235GSK-1614235DSP3235DSP 3235KGA3235KGA 3235GSK1614235GSK 1614235SGLTSodium-dependent glucose cotransportersChronicconstipationselectivegastrointestinaldisorderantidiabeticInhibitorinhibitorinhibit

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Mizagliflozin
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