1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Mizagliflozin

Mizagliflozin (Synonyms: DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base)

Cat. No.: HY-17638 Purity: 99.35%
Handling Instructions

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation.

For research use only. We do not sell to patients.

Mizagliflozin Chemical Structure

Mizagliflozin Chemical Structure

CAS No. : 666843-10-3

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10 mM * 1 mL in DMSO USD 248 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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10 mg USD 350 In-stock
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25 mg USD 700 In-stock
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50 mg USD 1100 In-stock
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100 mg USD 1650 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation[1].

IC50 & Target

Ki: 27 nM (hSGLT1), 8170 nM (hSGLT2)[1]

In Vivo

Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect[1].
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (rat model of low-fiber-diet-induced constipation)[1]
Dosage: 3, 10, 30 mg/kg
Administration: Oral
Result: Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation.
Molecular Weight

564.67

Formula

C₂₈H₄₄N₄O₈

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (177.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7709 mL 8.8547 mL 17.7095 mL
5 mM 0.3542 mL 1.7709 mL 3.5419 mL
10 mM 0.1771 mL 0.8855 mL 1.7709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Mizagliflozin
Cat. No.:
HY-17638
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