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Results for "

schistosomiasis

" in MedChemExpress (MCE) Product Catalog:

標的別:	5-HT Receptor (2) Antibiotic (2) Bacterial (2) Biochemical Assay Reagents (1) Cathepsin (1) Drug Derivative (1) Fructose-1,6-bisphosphate aldolase (1) HDAC (2) Histone Demethylase (2) Keap1-Nrf2 (2) Parasite (23) Phosphatase (1) Prolyl Endopeptidase (PREP) (1) Reference Standards (2)
研究分野別:	Cancer (1) Infection (26) Inflammation/Immunology (3) Metabolic Disease (1)
クリックケミストリー:	Alkynes (1)

阻害剤およびアゴニスト

生化学アッセイ試薬

ペプチド

天然物

同位体標識化合物

クリックケミストリー

製品番号	製品名	Target	研究分野	構造式

HY-N3075

Phytol 3 Publications Verification (E)-Phytol	Parasite Bacterial Keap1-Nrf2	Infection Inflammation/Immunology
Phytol ((E)-Phytol) is an orally active diterpenoid alcohol that can be extracted from chlorophyll. Phytol has antioxidant, anti-inflammatory, anti-schistosomiasis and antibacterial activities .

HY-B0244

Praziquantel 2 Publications Verification	Parasite Antibiotic	Infection
Praziquantel is a broadly effective trematocide and cestocide, the initial effect of praziquantel on the schistosome may be an interaction of the drug with lipid constituents of the tegumental membrane. Praziquantel is used for the research of schistosomiasis .

HY-10416

Oxamniquine 1 Publications Verification	Parasite	Infection
Oxamniquine is a potent agent for the treatment of schistosomiasis.

HY-N10534

Lewis X trisaccharide Lewis X	Parasite	Infection Inflammation/Immunology Cancer
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-N3075R

Phytol (Standard) (E)-Phytol (Standard)	Reference Standards Parasite Bacterial Keap1-Nrf2	Infection Inflammation/Immunology
Phytol (Standard) is the analytical standard of Phytol. This product is intended for research and analytical applications. Phytol ((E)-Phytol) is an orally active diterpenoid alcohol that can be extracted from chlorophyll. Phytol has antioxidant, anti-inflammatory, anti-schistosomiasis and antibacterial activities[1][2][3].

HY-N4184

Licoflavone B	Parasite	Infection
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC₅₀, 23.78 µM) and ADPase (IC₅₀, 31.50 µM) activity. Anti-schistosomiasis activity .

HY-Y1890C

Cremophor EL-20	Biochemical Assay Reagents	Others
Cremophor EL-20 is a type of Cremophor EL. Cremophor EL is a nonionic surfactant .

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

HY-126057

(R)-Praziquantel	Parasite 5-HT Receptor	Infection
(R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer .

HY-126057S

(R)-Praziquantel-d11	Parasite 5-HT Receptor	Infection
(R)-Praziquantel-d₁₁ is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer .

HY-175184

LSD1-IN-44	Histone Demethylase	Infection
LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC₅₀ of 0.02  μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .

HY-101725A

(R)-Meclonazepam Ro 11-3624; Ro 11-3624/001	Parasite	Others
(R)-Meclonazepam (Ro 11-3624) is an inactive enantiomer of Meclonazepam. Meclonazepam is a benzodiazepine derivative with anti-schistosomiasis activities .

HY-161596

SmCB1-IN-1	Parasite Cathepsin	Infection
SmCB1-IN-1 (Compound 2h) is an inhibitor for S. mansoni cathepsin B1 (SmCB1) with an K_i of 0.05 μM . SmCB1-IN-1 exhibits selectivity toward human off-target cathepsins (29% and 37% inhibition for CatB and CatL at 20 μM). SmCB1-IN-1 inhibits 68% Schistosoma mansoni at 1 μM .

HY-131433

Teroxalene hydrochloride	Parasite	Infection
Teroxalene hydrochloride is an orally active schistosomiasis agent .

HY-B0244R

Praziquantel (Standard)	Reference Standards Parasite Antibiotic	Infection
Praziquantel (Standard) is the analytical standard of Praziquantel. This product is intended for research and analytical applications. Praziquantel is a broadly effective trematocide and cestocide, the initial effect of praziquantel on the schistosome may be an interaction of the drug with lipid constituents of the tegumental membrane. Praziquantel is used for the research of schistosomiasis .

HY-151433

Antiparasitic agent-10	Parasite	Infection
Antiparasitic agent-10 (Compound 94) is an anti-parasitic agent, shows anti-schistosomal activity. Antiparasitic agent-10 shows activity against adults of Schistosoma mansoni, and can be used in Schistosomiasis research .

HY-168547S

AR89-d6	Parasite	Infection
AR89-d6 (Compound AR102) is a deuterated derivative of AR89 with oral activity. AR89-d6 demonstrates activity against S. mansoni, S. haematobium, and S. japonicum, and can be utilized for research on schistosomiasis .

HY-124782

HDAC8-IN-8	HDAC	Infection
HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC₅₀ values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC₅₀ values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research .

HY-175185

MC3935	Histone Demethylase	Infection
MC3935 is a LSD1 inhibitor with an IC₅₀ of 0.52  μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .

HY-144098

HDAC8-IN-2	Parasite HDAC	Others
HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC₅₀ values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs .

HY-182621

MB4253	Parasite	Infection
MB4253 is an orally active aliphatic amide and schistosomicidal agent. MB4253 acts against Schistosoma mansoni. MB4253 can be used for the research of schistosomiasis .

HY-183178

Teroxalene	Parasite	Infection
Teroxalene (Compound VII) is a piperazine-based Schistosomicide. Teroxalene is used for the research of schistosomiasis .

HY-N18199

rel-Bornyl cinnamate	Parasite	Infection
rel-Bornyl cinnamate is an anti-schistosomal agent. rel-Bornyl cinnamate induces round, dark morphological changes, followed by degeneration in Schistosoma mansoni schistosomula. rel-Bornyl cinnamate can be used for the research of schistosomiasis .

HY-23317

N-Methyl-4-(8-phenoxyoctoxy)aniline	Parasite	Infection
N-Methyl-4-(8-phenoxyoctoxy) aniline (Compound 3568) is an anti-schistosomal agent. N-Methyl-4-(8-phenoxyoctoxy) aniline exhibits definite anti-Schistosoma mansoni activity in mouse models, but has high acute toxicity. N-Methyl-4-(8-phenoxyoctoxy) aniline can be used in studies related to schistosomiasis .

HY-180339

Antiparasitic agent-36		Infection
Antiparasitic agent-36 is a Schistosoma mansoni-targeting antischistosomal agent that exhibits antischistosomal activity in mice with oral effectiveness, and is a nuclear substituted monoaminophenoxyalkane. Antiparasitic agent-36 can be used for the research of schistosomiasis .

HY-N19880

Oleanoglycotoxin A	Drug Derivative	Infection
Oleanoglycotoxin A is a saponin present in the berries of Phytolacca dodecandra, with antifertility and molluscicidal activities. Oleanoglycotoxin A prevents pregnancy, reduces the number of embryos, inhibits implantation, terminates established pregnancy, and kills Biomphalaria glabrata. Oleanoglycotoxin A can be used in studies related to schistosomiasis .

HY-180337

Antiparasitic agent-38	Parasite	Infection
Antiparasitic agent-38 is an orally active antischistosomal agent that effectively clears Schistosoma mansoni infections in mice (single oral LD₅₀=0.8 g/kg) and significantly inhibits S. mansoni infection. Antiparasitic agent-38 can be used for research on schistosomiasis, particularly S. mansoni infection .

HY-W054427

Ro 13-3978	Parasite	Infection Metabolic Disease
Ro 13-3978 is an orally active antischistosomal agent. Ro 13-3978 exhibits excellent in vivo antischistosomal activity against juvenile and adult Schistosoma mansoni infections. Ro 13-3978 shows no in vivo activity against E. caproni and F. hepatica. Ro 13-3978 blocks dihydrotestosterone-induced proliferation of androgen-dependent cells. Ro 13-3978 can be used in research related to schistosomiasis .

HY-180388

Stibophen	Fructose-1,6-bisphosphate aldolase Parasite Phosphatase	Infection
Stibophen is a potent antiparasitic agent is effective against Litomosoides carinii, Dipetalonema witei, and Brugia pahangi. Stibophen inhibits lactate accumulation and phosphofructokinases (PFK) activity in adult filariids. Stibophen also inhibits Ascaris and Hymenolepis diminuta PFK without inhibiting mammalian liver PFK. Stibophen can be used for the research of schistosomiasis and filariid infections .

Cremophor EL-20	生化学アッセイ試薬
Cremophor EL-20 is a type of Cremophor EL. Cremophor EL is a nonionic surfactant .

製品番号	製品名	Target	研究分野

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

製品番号	製品名	Category	Target	構造式

HY-N3075

Phytol 3 Publications Verification (E)-Phytol	Infection Microorganisms Ginkgoaceae Classification of Application Fields Terpenoids Diterpenoids Plants Ginkgo biloba Disease Research Fields Source Classification Food Research	Parasite Bacterial Keap1-Nrf2
Phytol ((E)-Phytol) is an orally active diterpenoid alcohol that can be extracted from chlorophyll. Phytol has antioxidant, anti-inflammatory, anti-schistosomiasis and antibacterial activities .

HY-N10534

Lewis X trisaccharide Lewis X	Infection Structural Classification Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-N3075R

Phytol (Standard) (E)-Phytol (Standard)	Structural Classification Microorganisms Ginkgoaceae Terpenoids Diterpenoids Plants Ginkgo biloba Source Classification	Reference Standards Parasite Bacterial Keap1-Nrf2
Phytol (Standard) is the analytical standard of Phytol. This product is intended for research and analytical applications. Phytol ((E)-Phytol) is an orally active diterpenoid alcohol that can be extracted from chlorophyll. Phytol has antioxidant, anti-inflammatory, anti-schistosomiasis and antibacterial activities[1][2][3].

HY-N4184

Licoflavone B	Infection Flavonoids Classification of Application Fields Flavones Leguminosae Glycyrrhiza inflata Batal. Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Parasite
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC₅₀, 23.78 µM) and ADPase (IC₅₀, 31.50 µM) activity. Anti-schistosomiasis activity .

HY-N18199

rel-Bornyl cinnamate	Structural Classification Microorganisms Simple Phenylpropanols Phenylpropanoids Source Classification	Parasite
rel-Bornyl cinnamate is an anti-schistosomal agent. rel-Bornyl cinnamate induces round, dark morphological changes, followed by degeneration in Schistosoma mansoni schistosomula. rel-Bornyl cinnamate can be used for the research of schistosomiasis .

HY-N19880

Oleanoglycotoxin A	Structural Classification Ketones, Aldehydes, Acids Phytolacca dodecandra L'Hér. Plants Phytolaccaceae Source Classification	Drug Derivative
Oleanoglycotoxin A is a saponin present in the berries of Phytolacca dodecandra, with antifertility and molluscicidal activities. Oleanoglycotoxin A prevents pregnancy, reduces the number of embryos, inhibits implantation, terminates established pregnancy, and kills Biomphalaria glabrata. Oleanoglycotoxin A can be used in studies related to schistosomiasis .

製品番号	製品名	構造式

HY-126057S

(R)-Praziquantel-d11
(R)-Praziquantel-d₁₁ is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer .

HY-168547S

AR89-d6
AR89-d6 (Compound AR102) is a deuterated derivative of AR89 with oral activity. AR89-d6 demonstrates activity against S. mansoni, S. haematobium, and S. japonicum, and can be utilized for research on schistosomiasis .

製品番号	製品名		Classification

HY-175185

MC3935		Alkynes
MC3935 is a LSD1 inhibitor with an IC₅₀ of 0.52  μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .

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