1. Anti-infection
    Neuronal Signaling
    GPCR/G Protein
  2. Parasite
    5-HT Receptor
  3. (R)-Praziquantel D11

(R)-Praziquantel D11 

Cat. No.: HY-126057S
Handling Instructions

(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer.

For research use only. We do not sell to patients.

(R)-Praziquantel D11 Chemical Structure

(R)-Praziquantel D11 Chemical Structure

CAS No. : 1399880-38-6

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Description

(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer[1].

IC50 & Target[1]

5-HT2B Receptor

 

Antischistosomal

 

In Vitro

(R)-Praziquantel ((R)-PZQ) is a G-protein-coupled receptor ligand. (R)-Praziquantel modulation of serotoninergic signaling occurs over a concentration range sufficient to regulate vascular tone of the mesenteric blood vessels where the adult parasites reside within their host. The important anthelmintic is supported by a broad, cross species polypharmacology with (R)-Praziquantel modulating signaling events in both host and parasite[1].

Molecular Weight

323.47

Formula

C₁₉H₁₃D₁₁N₂O₂

CAS No.

1399880-38-6

SMILES

O=C1CN(C(C2([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])=O)C[[email protected]]3([H])N1CCC4=C3C=CC=C4

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(R)-Praziquantel D11Parasite5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptoranthelminticpraziquantelSchistosomiasis5-HT2Bantischistosomal,eutomerInhibitorinhibitorinhibit

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