1. Anti-infection
  2. Parasite
  3. Praziquantel

Praziquantel 

Cat. No.: HY-B0244 Purity: 99.65%
Handling Instructions

Praziquantel is an anthelmintic effective against flatworms.

For research use only. We do not sell to patients.

Praziquantel Chemical Structure

Praziquantel Chemical Structure

CAS No. : 55268-74-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Description

Praziquantel is an anthelmintic effective against flatworms. Target: Antiparasitic Praziquantel is the drug of choice for treatment of all human schistosomes. Infected mice were treated with increasing Praziquantel doses until the highest dose of 3 × 300 mg/Kg was reached. The effect of Praziquantel treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to Praziquantel. In our experiments we also observed that female worms were more susceptible to Praziquantel than male worms [1, 2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (160.05 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2009 mL 16.0046 mL 32.0092 mL
5 mM 0.6402 mL 3.2009 mL 6.4018 mL
10 mM 0.3201 mL 1.6005 mL 3.2009 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

312.41

Formula

C₁₉H₂₄N₂O₂

CAS No.

55268-74-1

SMILES

O=C1CN(C(C2CCCCC2)=O)CC3N1CCC4=C3C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Praziquantel
Cat. No.:
HY-B0244
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Praziquantel

Cat. No.: HY-B0244