Praziquantel

Name: Praziquantel
Brand: MedChemExpress
SKU: HY-B0244
Rating: 5.0 (2 reviews)

Cat. No.: HY-B0244 Purity: 99.65%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Praziquantel is a broadly effective trematocide and cestocide, the initial effect of praziquantel on the schistosome may be an interaction of the drug with lipid constituents of the tegumental membrane. Praziquantel is used for the research of schistosomiasis.

For research use only. We do not sell to patients.

Praziquantel Chemical Structure

CAS No. : 55268-74-1

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Praziquantel:

Praziquantel-d₁₁ Get quote
Praziquantel (Standard) Get quote

2 Publications Citing Use of MCE Praziquantel

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Schistosome

Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	CC₅₀	> 200 μM Compound: PQZ	Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 33236902]
HepG2	CC₅₀	101.05 μM Compound: PZQ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34536671]
HepG2	CC₅₀	142.8 μM Compound: PZQ	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 34536671]
L6	IC₅₀	> 96 μM Compound: Praziquantel	Cytotoxicity against rat L6 cells incubated for 690 hrs by Alamar blue assay Cytotoxicity against rat L6 cells incubated for 690 hrs by Alamar blue assay	[PMID: 23013253]
SH-SY5Y	CC₅₀	> 200 μM Compound: PQZ	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 33236902]

In Vitro

Praziquantel (0.1-10 μM) enhances the tension produced by the musculature of male Schistosomajaponicum in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

312.41

Formula

C₁₉H₂₄N₂O₂

CAS No.

55268-74-1

Appearance

Solid

Color

White to off-white

SMILES

O=C1CN(C(C2CCCCC2)=O)CC3N1CCC4=C3C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (160.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2009 mL	16.0046 mL	32.0092 mL
5 mM	0.6402 mL	3.2009 mL	6.4018 mL
10 mM	0.3201 mL	1.6005 mL	3.2009 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 12.5 mg/mL (40.01 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C
Protocol 2

Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 30 mg/mL (96.03 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (249 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Qian Sun, et al. The cytotoxicity study of praziquantel enantiomers. Drug Des Devel Ther. 2016 Jun 24;10:2061-8. [Content Brief]

[2]. Andrews P, et al. Praziquantel: mechanisms of anti-schistosomal activity. Pharmacol Ther. 1985;29(1):129-56. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2009 mL	16.0046 mL	32.0092 mL	80.0230 mL
	5 mM	0.6402 mL	3.2009 mL	6.4018 mL	16.0046 mL
	10 mM	0.3201 mL	1.6005 mL	3.2009 mL	8.0023 mL
	15 mM	0.2134 mL	1.0670 mL	2.1339 mL	5.3349 mL
	20 mM	0.1600 mL	0.8002 mL	1.6005 mL	4.0012 mL
	25 mM	0.1280 mL	0.6402 mL	1.2804 mL	3.2009 mL
	30 mM	0.1067 mL	0.5335 mL	1.0670 mL	2.6674 mL
	40 mM	0.0800 mL	0.4001 mL	0.8002 mL	2.0006 mL
	50 mM	0.0640 mL	0.3201 mL	0.6402 mL	1.6005 mL
	60 mM	0.0533 mL	0.2667 mL	0.5335 mL	1.3337 mL
	80 mM	0.0400 mL	0.2001 mL	0.4001 mL	1.0003 mL
	100 mM	0.0320 mL	0.1600 mL	0.3201 mL	0.8002 mL

Praziquantel Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Praziquantel55268-74-1ParasiteAntibiotictrematocidecestocideschistosomiasisInhibitorinhibitorinhibit

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Praziquantel

Customer Review

Other Forms of Praziquantel:

Praziquantel Related Antibodies

2 Publications Citing Use of MCE Praziquantel

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•Related Screening Libraries:

•Related Small Molecules:

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View All Antibiotic Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Praziquantel Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Praziquantel Related Classifications

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