2. Apoptosis Anti-infection
  3. Apoptosis Antibiotic
  4. Swainsonine

Swainsonine  (Synonyms: スワインソニン; Tridolgosir)

製品番号: HY-N6722 純度: 99.95%
COA 取扱説明書 Technical Support

Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.

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Swainsonine

Swainsonine 構造式

CAS 番号 : 72741-87-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water USD 1298 お問い合わせ
Solid
1 mg $300 在庫あり
5 mg $1180 在庫あり
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Swainsonine 関連抗体

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製品説明

Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity[1][2][3].

体外実験

Swainsonine (0-40 μM; 12 h) shows antiproliferative activity in U251 and LN444 cells[2].
Swainsonine (30 μM; 12 h) induces apoptosis and cell cycle arrest at G2/M phase, and decreases the expression of CyclinD1 and CDK4 protein levels, increases the expression of p16 protein level[2].
Swainsonine (30 μM; 12 h) reduces glioma cell migration and invasion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Swainsonine 関連抗体

Cell Viability Assay[2]

Cell Line: U251, LN444 cells
Concentration: 0, 10, 20, 30, 40 µM
Incubation Time: 12 h
Result: Inhibited cell viability in a dose-dependent manner, and shows no cytotoxicity in normal brain cells.

Cell Cycle Analysis[2]

Cell Line: U251 cells
Concentration: 30 µM
Incubation Time: 12 h
Result: Induced cell cycle arrest at G2/M phase.

Apoptosis Analysis[2]

Cell Line: U251 cells
Concentration: 30 µM
Incubation Time: 12 h
Result: Induced apoptosis with the cleaved-Caspase-3 and cleaved-Caspase-9 expression were obviously increased.
体内実験

Swainsonine (1 mg/kg; i.p.; twice daily for ten days) and cisplatin increases the anti-tumor efficacy in mouse[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eighty-seven sixty-day-old male C57BL/6 mice[3]
Dosage: 1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days)
Administration: I.p.; twice daily for ten days
Result: Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.
分子量

173.21

分子式

C8H15NO3
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

O[C@@H]1[C@H](O)CN2CCC[C@@H](O)[C@]12[H]
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 10 mg/mL (57.73 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 4.17 mg/mL (24.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7733 mL 28.8667 mL 57.7334 mL
5 mM 1.1547 mL 5.7733 mL 11.5467 mL
10 mM 0.5773 mL 2.8867 mL 5.7733 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.95%

COA (252 KB) HNMR (139 KB) RP-HPLC (194 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.7733 mL 28.8667 mL 57.7334 mL 144.3335 mL
5 mM 1.1547 mL 5.7733 mL 11.5467 mL 28.8667 mL
10 mM 0.5773 mL 2.8867 mL 5.7733 mL 14.4333 mL
15 mM 0.3849 mL 1.9244 mL 3.8489 mL 9.6222 mL
20 mM 0.2887 mL 1.4433 mL 2.8867 mL 7.2167 mL
DMSO 25 mM 0.2309 mL 1.1547 mL 2.3093 mL 5.7733 mL
30 mM 0.1924 mL 0.9622 mL 1.9244 mL 4.8111 mL
40 mM 0.1443 mL 0.7217 mL 1.4433 mL 3.6083 mL
50 mM 0.1155 mL 0.5773 mL 1.1547 mL 2.8867 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Swainsonine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Swainsonine72741-87-8TridolgosirApoptosisAntibioticantiproliferativeapoptosisG2/M phaseU251 cellsanti-tumorInhibitorinhibitorinhibit

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