2. Metabolic Enzyme/Protease
  3. MMP
  4. Tanomastat

Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models.

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Tanomastat

Tanomastat Estructura química

No. CAS : 179545-77-8

Tamaño Precio Stock Cantidad
500 μg En stock

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Other Forms of Tanomastat:

Tanomastat Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas MMP:

Ver todas las isoformas
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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Descripciòn

Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3].

IC50 & Target[1]

MMP-2

11 nM (Ki)

MMP-3

143 nM (Ki)

MMP-9

301 nM (Ki)

MMP-13

1470 nM (Ki)

In Vitro

Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation[2].
Tanomastat (BAY 12-9566) (1-00 µM; 5 days) inhibits tubule formation completely at 15-100 µM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tanomastat Related Antibodies
In Vivo

Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to eight-week-old female BALB/c nude mice (bearing MDA-MB-435 cells)[3]
Dosage: 100 mg/kg
Administration: p.o.; daily for a 7-week period
Result: Inhibited local tumor regrowth by 58% without causing any toxic effect, and inhibited the number and volume of lung metastases by 57 and 88%, respectively.
Peso molecular

410.91

Fòrmula

C23H19ClO3S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C2=CC=C(C(C[C@H](CSC3=CC=CC=C3)C(O)=O)=O)C=C2)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 25 mg/mL (60.84 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4336 mL 12.1681 mL 24.3362 mL
5 mM 0.4867 mL 2.4336 mL 4.8672 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.74%

SDS (393 KB)

COA (250 KB) HNMR (124 KB) RP-HPLC (242 KB) MS (209 KB) Elemental Analysis Report (107 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4336 mL 12.1681 mL 24.3362 mL 60.8406 mL
5 mM 0.4867 mL 2.4336 mL 4.8672 mL 12.1681 mL
10 mM 0.2434 mL 1.2168 mL 2.4336 mL 6.0841 mL
15 mM 0.1622 mL 0.8112 mL 1.6224 mL 4.0560 mL
20 mM 0.1217 mL 0.6084 mL 1.2168 mL 3.0420 mL
25 mM 0.0973 mL 0.4867 mL 0.9734 mL 2.4336 mL
30 mM 0.0811 mL 0.4056 mL 0.8112 mL 2.0280 mL
40 mM 0.0608 mL 0.3042 mL 0.6084 mL 1.5210 mL
50 mM 0.0487 mL 0.2434 mL 0.4867 mL 1.2168 mL
60 mM 0.0406 mL 0.2028 mL 0.4056 mL 1.0140 mL
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Tanomastat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tanomastat179545-77-8BAY 12-9566MMPMatrix metalloproteinasesorallycarboxylinvasivemetastatictumorMDA-MB-435cellslungmetastasesInhibitorinhibitorinhibit

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Nombre del producto:
Tanomastat
Cat. No.:
HY-12168
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