2. Metabolic Enzyme/Protease Anti-infection Immunology/Inflammation Apoptosis
  3. Renin Bacterial Interleukin Related TNF Receptor
  4. Theasinensin C

Theasinensin C is an orally effective renin inhibitor and gut microbiota modulator, with an IC50 of 40.21 μM against renin activity. Theasinensin C selectively enriches Akkermansia muciniphila in the gut microbiota, enhances the Akkermansia muciniphila-mediated hydrolysis of the PTS domain of mucin, drives the accumulation of luminal glutamine and serine, and regulates the gut-kidney-liver glutamine/serine metabolic signaling pathway to promote creatine biosynthesis. Theasinensin C improves cognitive function, reduces pro-inflammatory cytokines, alleviates neuropathological changes and restores intestinal barrier integrity. Theasinensin C can be used in research related to hypertension and neuroinflammation induced by high-fructose diet.

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Theasinensin C

Theasinensin C 構造式

CAS 番号 : 89013-69-4

容量 価格（税別） 在庫状況 数量
5 mg $580 お問い合わせ 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
10 mg $895 お問い合わせ 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
25 mg $1430 お問い合わせ 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
50 mg $2000 お問い合わせ 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
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Theasinensin C 関連抗体

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Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

TNF Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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製品説明

Theasinensin C is an orally effective renin inhibitor and gut microbiota modulator, with an IC50 of 40.21 μM against renin activity. Theasinensin C selectively enriches Akkermansia muciniphila in the gut microbiota, enhances the Akkermansia muciniphila-mediated hydrolysis of the PTS domain of mucin, drives the accumulation of luminal glutamine and serine, and regulates the gut-kidney-liver glutamine/serine metabolic signaling pathway to promote creatine biosynthesis. Theasinensin C improves cognitive function, reduces pro-inflammatory cytokines, alleviates neuropathological changes and restores intestinal barrier integrity. Theasinensin C can be used in research related to hypertension and neuroinflammation induced by high-fructose diet[1][2].

Cellular Effect
Cell Line Type Value Description References
H9 EC50
6 6
Compound: 30 (R)
Inhibition of HIV-1 replication in H9 (human lymphoma) cells.
Inhibition of HIV-1 replication in H9 (human lymphoma) cells.
10.1016/0960-894X(96)00095-9
体外実験

Theasinensin C (48 h) enhances Akkermansia muciniphila XJ 240720-mediated degradation of the mucin PTS domain, resulting in a significant increase in luminal L-glutamine and L-serine levels[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Theasinensin C 関連抗体
体内実験

Theasinensin C (150 mg/kg/day; oral gavage; daily; 8 weeks) mitigates HFrD-induced neuroinflammation in male C57BL/6J mice by improving cognitive function, reducing systemic and central inflammatory markers, restoring intestinal barrier integrity, and remodeling gut microbiota to enrich beneficial taxa like Akkermansia muciniphila[3].
Theasinensin C (150 mg/kg/day; oral gavage; daily; 8 weeks) attenuates HFrD-induced neuroinflammation in antibiotic-pretreated germ-free male C57BL/6J mice, with improvements in cognitive function and reduction of central inflammatory markers, though efficacy is enhanced when combined with Akkermansia muciniphila-derived metabolites[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (8-week-old male, SPF grade, HFrD-induced neuroinflammation)[3]
Dosage: 150 mg/kg/day
Administration: oral gavage; daily; 8 weeks
Result: Shortened escape latency in MWM training, increased percentage of distance and time spent in the target quadrant, and increased number of platform crossings compared to HFrD controls.
Decreased serum levels of LPS, TNF-α, and IL-6, and increased serum IL-10 levels compared to HFrD controls.
Reduced number of damaged neurons in the hippocampus and cortex; decreased mean fluorescence density of GFAP and IBA-1 in the hippocampus; downregulated hippocampal and cortical mRNA expression of Il-6, Tnf-α, Il-1β, Mcp-1, iNos, and Cox-2 compared to HFrD controls.
Alleviated colonic shortening, submucosal edema, inflammatory infiltration, crypt damage, and goblet cell loss; downregulated colonic mRNA expression of Tnf-α, Il-6, Il-1β, and Mcp-1; upregulated colonic mRNA expression of Zo-1, Occludin, Claudin-1, and Muc1 compared to HFrD controls.
Selectively enriched beneficial taxa; suppressed pro-inflammatory taxa including Desulfovibrio desulfuricans, Neisseria mucosa, Helicobacter hepaticus, and Ruminococcus gnavus compared to HFrD controls; restored HFrD-reduced levels of acetate, propionate, i-butyrate, n-butyrate, n-valerate, lactic acid, and total acids in colonic contents, and upregulated intestinal SCFA receptor genes Ffar2 and Ffar3.
Animal Model: C57BL/6J (8-week-old male, SPF grade, antibiotic-pretreated germ-free, HFrD-induced neuroinflammation)[3]
Dosage: 150 mg/kg/day
Administration: oral gavage; daily; 8 weeks
Result: Reduced escape latency in MWM training, increased percentage of distance and time spent in the target quadrant, and increased number of platform crossings compared to HFrD controls (efficacy was less than the combined metabolite group of theasinensin C and Akkermansia muciniphila, but greater than HFrD controls).
Reduced number of damaged neurons in the hippocampus and cortex; decreased mean fluorescence density of GFAP and IBA-1 in the hippocampus; downregulated hippocampal and cortical mRNA expression of Il-6, Tnf-α, Il-1β, Mcp-1, iNos, and Cox-2 compared to HFrD controls.
分子量

610.52

分子式

C30H26O14
CAS 番号
SMILES

OC1=CC(O[C@@H]([C@@H](C2)O)C3=C(C4=C([C@H]5OC6=C(C[C@H]5O)C(O)=CC(O)=C6)C=C(O)C(O)=C4O)C(O)=C(O)C(O)=C3)=C2C(O)=C1
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献
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Theasinensin C Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Theasinensin C89013-69-4ReninBacterialInterleukin RelatedTNF ReceptorILTumor Necrosis Factor ReceptorTNFRcreatine biosynthesisrenin-angiotensin systemAkkermansia muciniphilahigh-fructose diet-induced neuroinflammationmucin PTS domainserineC57BL/6J micehypertensionreninglutamineInhibitorinhibitorinhibit

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Theasinensin C
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