2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. TIQ-A

TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent.

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TIQ-A

TIQ-A 構造式

CAS 番号 : 420849-22-5

容量 価格（税別） 在庫状況 数量
1 mg $95 在庫あり
5 mg $200 在庫あり
10 mg $350 在庫あり
25 mg $650 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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TIQ-A 関連抗体

Top Publications Citing Use of Products

PARP アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1].

IC50 & Target

TNKS2

24 nM (IC50)

PARP2

210 nM (IC50)

PARP15

230 nM (IC50)

PARP10

>10 μM (IC50)

PARP14

>10 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
> 100 μM
Compound: 1, TIQ-A
Inhibition of tankyrase-1 function in human HeLa cells
Inhibition of tankyrase-1 function in human HeLa cells
10.1039/C1MD00021G
分子量

201.24

分子式

C11H7NOS
CAS 番号
Appearance

Solid

Color

Light green to green

SMILES

O=C1NC2=C(C3=C1C=CC=C3)C=CS2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (621.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9692 mL 24.8460 mL 49.6919 mL
5 mM 0.9938 mL 4.9692 mL 9.9384 mL
10 mM 0.4969 mL 2.4846 mL 4.9692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9692 mL 24.8460 mL 49.6919 mL 124.2298 mL
5 mM 0.9938 mL 4.9692 mL 9.9384 mL 24.8460 mL
10 mM 0.4969 mL 2.4846 mL 4.9692 mL 12.4230 mL
15 mM 0.3313 mL 1.6564 mL 3.3128 mL 8.2820 mL
20 mM 0.2485 mL 1.2423 mL 2.4846 mL 6.2115 mL
25 mM 0.1988 mL 0.9938 mL 1.9877 mL 4.9692 mL
30 mM 0.1656 mL 0.8282 mL 1.6564 mL 4.1410 mL
40 mM 0.1242 mL 0.6211 mL 1.2423 mL 3.1057 mL
50 mM 0.0994 mL 0.4969 mL 0.9938 mL 2.4846 mL
60 mM 0.0828 mL 0.4141 mL 0.8282 mL 2.0705 mL
80 mM 0.0621 mL 0.3106 mL 0.6211 mL 1.5529 mL
100 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2423 mL
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TIQ-A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIQ-A420849-22-5PARPpoly ADP ribose polymeraseADP-ribosylationADP-ribosyltransferasetankyrasespoly-ARTInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-121719
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