TRPM8 antagonist 3

Art. -Nr.: HY-145124 Reinheit: 99.51%: Data Sheet
COA

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Handling Instructions
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TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC₅₀ value of 11 nM.

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TRPM8 antagonist 3 Chemische Struktur

CAS. Nr. : 2102179-29-1

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Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle TRP Channel Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

Biologische Aktivität
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Beschreibung

TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC₅₀ value of 11 nM.

Molekulargewicht

292.31

Formel

C₁₃H₁₂N₂O₄S

CAS. Nr.

2102179-29-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1OCCC1)C2=C(O)N=C(C3=C(O)C=CC=C3)S2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (85.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4210 mL	17.1051 mL	34.2103 mL
5 mM	0.6842 mL	3.4210 mL	6.8421 mL
10 mM	0.3421 mL	1.7105 mL	3.4210 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.51%

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Data Sheet (274 KB) SDS (251 KB)

COA (255 KB) LCMS (107 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4210 mL	17.1051 mL	34.2103 mL	85.5256 mL
	5 mM	0.6842 mL	3.4210 mL	6.8421 mL	17.1051 mL
	10 mM	0.3421 mL	1.7105 mL	3.4210 mL	8.5526 mL
	15 mM	0.2281 mL	1.1403 mL	2.2807 mL	5.7017 mL
	20 mM	0.1711 mL	0.8553 mL	1.7105 mL	4.2763 mL
	25 mM	0.1368 mL	0.6842 mL	1.3684 mL	3.4210 mL
	30 mM	0.1140 mL	0.5702 mL	1.1403 mL	2.8509 mL
	40 mM	0.0855 mL	0.4276 mL	0.8553 mL	2.1381 mL
	50 mM	0.0684 mL	0.3421 mL	0.6842 mL	1.7105 mL
	60 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4254 mL
	80 mM	0.0428 mL	0.2138 mL	0.4276 mL	1.0691 mL