YM-31636 free base

Name: YM-31636 free base
Brand: MedChemExpress
SKU: HY-167902
Rating: 4.5 (0 reviews)

製品番号: HY-167902 純度: 98.78%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

YM-31636 free base is an orally active, potent and selective 5-HT₃ receptor agonist with a K_i value of 0.2 nM. YM-31636 free base induces contraction of isolated guinea pig distal colon. YM-31636 free base induces tachycardia with the relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium. YM-31636 free base is promising for research of constipation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

YM-31636 free base 構造式

CAS 番号 : 159081-22-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 390	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 390	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$355	在庫あり	Estimated Time of Arrival: December 31
10 mg	$570	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1145	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1780	在庫あり	Estimated Time of Arrival: December 31
100 mg	$2676	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

5-HT Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

5-HT₃ Receptor

0.2 nM (Ki)

5-HT_1F Receptor

>10000 nM (Ki)

5-HT_2A Receptor

>10000 nM (Ki)

分子量

253.32

分子式

C₁₄H₁₁N₃S

CAS 番号

159081-22-8

Appearance

Solid

Color

Yellow to brown

SMILES

C1(CC2=NC3=C(S2)CC4=C3C=CC=C4)=CN=CN1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (394.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9476 mL	19.7379 mL	39.4758 mL
5 mM	0.7895 mL	3.9476 mL	7.8952 mL
10 mM	0.3948 mL	1.9738 mL	3.9476 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.05%

Select Batch:

データシート (274 KB) SDS (251 KB)

COA (250 KB) HNMR (141 KB) RP-HPLC (251 KB) LCMS (387 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ito H, et al. Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. Eur J Pharmacol. 2000 Dec 8;409(2):195-201. [Content Brief]

[2]. Kiso T, et al. A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain. Eur J Pharmacol. 2001 Nov 9;431(1):35-41. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9476 mL	19.7379 mL	39.4758 mL	98.6894 mL
	5 mM	0.7895 mL	3.9476 mL	7.8952 mL	19.7379 mL
	10 mM	0.3948 mL	1.9738 mL	3.9476 mL	9.8689 mL
	15 mM	0.2632 mL	1.3159 mL	2.6317 mL	6.5793 mL
	20 mM	0.1974 mL	0.9869 mL	1.9738 mL	4.9345 mL
	25 mM	0.1579 mL	0.7895 mL	1.5790 mL	3.9476 mL
	30 mM	0.1316 mL	0.6579 mL	1.3159 mL	3.2896 mL
	40 mM	0.0987 mL	0.4934 mL	0.9869 mL	2.4672 mL
	50 mM	0.0790 mL	0.3948 mL	0.7895 mL	1.9738 mL
	60 mM	0.0658 mL	0.3290 mL	0.6579 mL	1.6448 mL
	80 mM	0.0493 mL	0.2467 mL	0.4934 mL	1.2336 mL
	100 mM	0.0395 mL	0.1974 mL	0.3948 mL	0.9869 mL