159081-22-8
159081-22-8
Chemical Structure
YM-31636 free base
- No. CAS: 159081-22-8
- Formula:C14H11N3S
- Molecular Weight:253.32
InChIKey: SWXJBBYBDXFMGG-UHFFFAOYSA-N
SMILES: C1(CC2=NC3=C(S2)CC4=C3C=CC=C4)=CN=CN1
Biological Activity: YM-31636 free base is an orally active, potent and selective 5-HT3 receptor agonist with a Ki value of 0.2 nM. YM-31636 free base induces contraction of isolated guinea pig distal colon. YM-31636 free base induces tachycardia with the relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium. YM-31636 free base is promising for research of constipation[1][2].
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YM-31636 free base | 98.78% | YM-31636 free base is an orally active, potent and selective 5-HT3 receptor agonist with a Ki value of 0.2 nM. YM-31636 free base induces contraction of isolated guinea pig distal colon. YM-31636 free base induces tachycardia with the relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium. YM-31636 free base is promising for research of constipation. | ||||||||||||||||||||
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References
- [1]. Ito H, et al. Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. Eur J Pharmacol. 2000 Dec 8;409(2):195-201. [Content Brief]
- [2]. Kiso T, et al. A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain. Eur J Pharmacol. 2001 Nov 9;431(1):35-41. [Content Brief]
Keywords
