Zabofloxacin  (Synonyms: DW-224a Free base)

Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)^[1].

Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC₉₀: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC₉₀: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC₉₀: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

401.39

C₁₉H₂₀FN₅O₄

219680-11-2

Solid

White to off-white

CO/N=C1C2(CNC2)CN(C3=C(F)C=C4C(N(C5CC5)C=C(C(O)=O)C4=O)=N3)C/1

Room temperature in continental US; may vary elsewhere.

• [1]. Park HS, et al. Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae. Molecules. 2016 Nov 17;21(11). pii: E1562.  [Content Brief]