2. Metabolic Enzyme/Protease Cytoskeleton
  3. Endogenous Metabolite Lysyl Oxidase
  4. β-Aminopropionitrile

β-Aminopropionitrile  (Synonyms: BAPN)

製品番号: HY-Y1750 純度: 99.84%
COA 取扱説明書 Technical Support

β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes. β-Aminopropionitrile can be used for the study of obesity.

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CAS 番号 : 151-18-8

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 60 在庫あり
Solution
10 mM * 1 mL in DMSO USD 60 在庫あり
Liquid
500 mg $55 在庫あり
1 g $88 在庫あり
5 g $281 在庫あり
10 g $420 在庫あり
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カスタマーレビュー

Based on 13 publication(s) in Google Scholar

Other Forms of β-Aminopropionitrile:

β-Aminopropionitrile 関連抗体

Top Publications Citing Use of Products

    β-Aminopropionitrile purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2025 Aug 27;14(1):111.  [Abstract]

    The BAPN (50 mg/kg; once every two days for four weeks; ip) treatment process for orthotopic xenograft mice model.

    β-Aminopropionitrile purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2025 Aug 27;14(1):111.  [Abstract]

    Western blot of vimentin, E-cadherin, CDKN1A in PBS-treated xenografts and BAPN (50 mg/kg; once every two days for four weeks; ip) -treated xenografts, using GAPDH as a control.

    β-Aminopropionitrile purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Morphology of cerebral edema in sham, HIBD and BAPN intervention groups (100 mg/kg/ip/day) at 72 h post-surgery.

    β-Aminopropionitrile purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Cell viability of BAPN (500 nM)-treated OGD/R-induced HT22 cells at 0 h, 12 h and 24 h after reoxygenation.

    β-Aminopropionitrile purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Representative TEM images of mitochondrial morphology in BAPN (500 nM) -incubated HT22 cells under OGD/R-induced conditions. Green arrows indicate normally shaped mitochondria, black arrows indicate damaged mitochondria.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes. β-Aminopropionitrile can be used for the study of obesity[1][2].

    IC50 & Target

    Lysyl Oxidase

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO IC50
    0.31 μM
    Compound: BAPN
    Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay
    Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay
    		[PMID: 31430136]
    体外実験

    β-Aminopropionitrile (BAPN) normalizes the expression of GLUT4 and adiponectin, and improves glucose uptake in an in vitro model of insulin resistance[1].
    β-Aminopropionitrile (500 μM; 72 h) blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibits invasion and migration capacities of cervical carcinoma cells in vitro[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    β-Aminopropionitrile 関連抗体

    Western Blot Analysis[1]

    Cell Line: 3T3-L1 adipocytes
    Concentration: 200 μM with 1.15 nM and 2.87 nM TNFα
    Incubation Time: 72 h
    Result: TNFα reduced expression of GLUT4 and adiponectin, and increased SOCS3 protein levels in these cells. And these effects were prevented.

    Cell Invasion Assay[2]

    Cell Line: HeLa and SiHa cells
    Concentration: 500 μM
    Incubation Time: 72 h
    Result: Significantly reduced hypoxia-elicited cell invasion in both cell models.

    Cell Migration Assay [2]

    Cell Line: HeLa and SiHa cells
    Concentration: 500 μM
    Incubation Time: 72 h
    Result: Decreased hypoxia-induced migration from 180 and 240% to 60 and 70% in HeLa and SiHa cells, respectively.

    Western Blot Analysis[2]

    Cell Line: HeLa and SiHa cells
    Concentration: 500 μM
    Incubation Time: 72 h
    Result: Effectively prevented hypoxia-induced downregulation of E-cadherin and strongly inhibited hypoxia-induced upregulation of α-SMA and vimentin.
    体内実験

    β-Aminopropionitrile (BAPN) (100 mg/kg/day; p.o.; 6 weeks) reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats[1].
    β-Aminopropionitrile monofumarate (1 g/kg/day; p.o.; 4 weeks) induces thoracic aortic dissection in C57BL/6 mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats of 150 g, high-fat diet (HFD) model[1]
    Dosage: 100 mg/kg/day
    Administration: In the drinking water, 6 weeks
    Result: Significantly prevented the rise in body weight in HFD rats, but not in animals that were fed a standard diet. Reduced the increase in the weight of white adipose tissue (both epididymal and lumbar) in obese animals and attenuated their enhanced adiposity. Improved fasted glucose and insulin levels and consequently reduced HOMA index in the HFD group. Improved insulin signalling in adipose tissue from obese animals.
    Animal Model: C57BL/6 mice[3]
    Dosage: 1 g/kg/day
    Administration: In the drinking water, 4 weeks
    Result: Induce thoracic aortic dissection (TAD) in all mice with 24 h of Ang II infusion. Caused 87% of C57BL/6 mice to develop TAD without Ang II.
    分子量

    70.09

    分子式

    C3H6N2
    CAS 番号
    Appearance

    Liquid (Density: 0.9584 g/cm3)

    Color

    Colorless to light yellow

    SMILES

    N#CCCN
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (1426.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 50 mg/mL (713.37 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 14.2674 mL 71.3369 mL 142.6737 mL
    5 mM 2.8535 mL 14.2674 mL 28.5347 mL
    10 mM 1.4267 mL 7.1337 mL 14.2674 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 3.25 mg/mL (46.37 mM); Clear solution

      This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 3.25 mg/mL (46.37 mM); Clear solution

      This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (1426.74 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.99%

    COA (242 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 14.2674 mL 71.3369 mL 142.6737 mL 356.6843 mL
    5 mM 2.8535 mL 14.2674 mL 28.5347 mL 71.3369 mL
    10 mM 1.4267 mL 7.1337 mL 14.2674 mL 35.6684 mL
    15 mM 0.9512 mL 4.7558 mL 9.5116 mL 23.7790 mL
    20 mM 0.7134 mL 3.5668 mL 7.1337 mL 17.8342 mL
    25 mM 0.5707 mL 2.8535 mL 5.7069 mL 14.2674 mL
    30 mM 0.4756 mL 2.3779 mL 4.7558 mL 11.8895 mL
    40 mM 0.3567 mL 1.7834 mL 3.5668 mL 8.9171 mL
    50 mM 0.2853 mL 1.4267 mL 2.8535 mL 7.1337 mL
    60 mM 0.2378 mL 1.1889 mL 2.3779 mL 5.9447 mL
    80 mM 0.1783 mL 0.8917 mL 1.7834 mL 4.4586 mL
    100 mM 0.1427 mL 0.7134 mL 1.4267 mL 3.5668 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    β-Aminopropionitrile Related Classifications

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    β-Aminopropionitrile151-18-8BAPNEndogenous MetaboliteLysyl Oxidasethoracic aortic dissectionGLUT4insulincervical carcinoma cellsHeLaSiHaobesitylysyl oxidaseInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-Y1750
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