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  4. 3-Aminopropionitrile fumarate (2:1)

3-Aminopropionitrile fumarate (2:1)  (Synonyms: Di-β-aminopropionitrile fumarate; β-Aminopropionitrile fumarate; β-Ammoniumpropionitrile hemifumarate)

Cat. No.: HY-107829 Purity: 99.96%
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3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

For research use only. We do not sell to patients.

CAS No. : 2079-89-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of 3-Aminopropionitrile fumarate (2:1):

3-Aminopropionitrile fumarate (2:1) Related Antibodies

Top Publications Citing Use of Products

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2025 Aug 27;14(1):111.  [Abstract]

    The BAPN (50 mg/kg; once every two days for four weeks; ip) treatment process for orthotopic xenograft mice model.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2025 Aug 27;14(1):111.  [Abstract]

    Western blot of vimentin, E-cadherin, CDKN1A in PBS-treated xenografts and BAPN (50 mg/kg; once every two days for four weeks; ip) -treated xenografts, using GAPDH as a control.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Morphology of cerebral edema in sham, HIBD and BAPN intervention groups (100 mg/kg/ip/day) at 72 h post-surgery.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Cell viability of BAPN (500 nM)-treated OGD/R-induced HT22 cells at 0 h, 12 h and 24 h after reoxygenation.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Representative TEM images of mitochondrial morphology in BAPN (500 nM) -incubated HT22 cells under OGD/R-induced conditions. Green arrows indicate normally shaped mitochondria, black arrows indicate damaged mitochondria.

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    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

    IC50 & Target

    Collagen[1].
    In Vivo

    Twenty days after the induction of tendinitis, intralesional treatment with 3-Aminopropionitrile fumarate (2:1) (BAPN-F) is performed and the contralateral limbs receive saline. A biopsy is obtained and gross and histopathological analysis is performed on the 150 th day of the experiment. The collagen fibrillar alignment pattern in the healing area is better in the 3-Aminopropionitrile fumarate (2:1) group submitted to controlled exercise than in the other group, as observed by sonographic and histopathologic examination. The present results indicate that 3-Aminopropionitrile fumarate (2:1) in combination with controlled loading improved scar remodeling and tendon wound collagen maturation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    256.26

    Formula

    C4H4O4.2C3H6N2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NCCC#N.OC(/C=C/C(O)=O)=O.NCCC#N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (390.23 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9023 mL 19.5114 mL 39.0229 mL
    5 mM 0.7805 mL 3.9023 mL 7.8046 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (390.23 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.96%

    SDS (420 KB)

    COA (251 KB) HNMR (244 KB) RP-HPLC (206 KB) MS (248 KB)

    Handling Instructions (2659 KB)
    References
    Animal Administration
    [1]

    Horses[1]
    Seven female and nine male horses are assigned at random to two groups (G1 and G2) submitted to different treatments after the induction of acute tendinitis. Each group consists of eight animals injected with type 1 collagenase, 1 mL, 2.5 mg/mL, in the middle metacarpal third into the superficial digital flexor tendons of both forelimbs. Twenty days after the injection of collagenase, one of the limbs (G1A/G2A) receives an injection of 3-Aminopropionitrile fumarate (2:1), 3 mL, 0.8 mg/mL, and the other limb (G1B) receives the same volume of buffered saline as control. Group one was left in box rest, and group two was submitted to controlled exercise during the experiment[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.9023 mL 19.5114 mL 39.0229 mL 97.5572 mL
    5 mM 0.7805 mL 3.9023 mL 7.8046 mL 19.5114 mL
    10 mM 0.3902 mL 1.9511 mL 3.9023 mL 9.7557 mL
    15 mM 0.2602 mL 1.3008 mL 2.6015 mL 6.5038 mL
    20 mM 0.1951 mL 0.9756 mL 1.9511 mL 4.8779 mL
    25 mM 0.1561 mL 0.7805 mL 1.5609 mL 3.9023 mL
    30 mM 0.1301 mL 0.6504 mL 1.3008 mL 3.2519 mL
    40 mM 0.0976 mL 0.4878 mL 0.9756 mL 2.4389 mL
    50 mM 0.0780 mL 0.3902 mL 0.7805 mL 1.9511 mL
    60 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6260 mL
    80 mM 0.0488 mL 0.2439 mL 0.4878 mL 1.2195 mL
    100 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9756 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    3-Aminopropionitrile fumarate (2:1) Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    3-Aminopropionitrile fumarate (2:1)2079-89-2Di-β-aminopropionitrileβ-Aminopropionitrile β-Ammoniumpropionitrile hemifumarateMMPMatrix metalloproteinasesInhibitorinhibitorinhibit

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