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3-Aminopropionitrile fumarate 2:1 (Synonyms: Di-β-aminopropionitrile fumarate; β-Aminopropionitrile fumarate; β-Ammoniumpropionitrile hemifumarate)

Cat. No.: HY-107829
Handling Instructions

3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

For research use only. We do not sell to patients.

3-Aminopropionitrile fumarate 2:1 Chemical Structure

3-Aminopropionitrile fumarate 2:1 Chemical Structure

CAS No. : 2079-89-2

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

IC50 & Target

Collagen[1].

In Vivo

Twenty days after the induction of tendinitis, intralesional treatment with 3-Aminopropionitrile fumarate (2:1) (BAPN-F) is performed and the contralateral limbs receive saline. A biopsy is obtained and gross and histopathological analysis is performed on the 150 th day of the experiment. The collagen fibrillar alignment pattern in the healing area is better in the 3-Aminopropionitrile fumarate (2:1) group submitted to controlled exercise than in the other group, as observed by sonographic and histopathologic examination. The present results indicate that 3-Aminopropionitrile fumarate (2:1) in combination with controlled loading improved scar remodeling and tendon wound collagen maturation[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3714 mL 26.8572 mL 53.7143 mL
5 mM 1.0743 mL 5.3714 mL 10.7429 mL
10 mM 0.5371 mL 2.6857 mL 5.3714 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Horses[1]
Seven female and nine male horses are assigned at random to two groups (G1 and G2) submitted to different treatments after the induction of acute tendinitis. Each group consists of eight animals injected with type 1 collagenase, 1 mL, 2.5 mg/mL, in the middle metacarpal third into the superficial digital flexor tendons of both forelimbs. Twenty days after the injection of collagenase, one of the limbs (G1A/G2A) receives an injection of 3-Aminopropionitrile fumarate (2:1), 3 mL, 0.8 mg/mL, and the other limb (G1B) receives the same volume of buffered saline as control. Group one was left in box rest, and group two was submitted to controlled exercise during the experiment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

186.17

Formula

C₇H₁₀N₂O₄

CAS No.

2079-89-2

SMILES

OC(/C=C/C(O)=O)=O.NCCC#N

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
3-Aminopropionitrile fumarate 2:1
Cat. No.:
HY-107829
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3-Aminopropionitrile fumarate 2:1

Cat. No.: HY-107829