1. Metabolic Enzyme/Protease
  2. MMP
  3. SB-3CT

SB-3CT 

Cat. No.: HY-12354 Purity: 99.35%
Handling Instructions

SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity.

For research use only. We do not sell to patients.

SB-3CT Chemical Structure

SB-3CT Chemical Structure

CAS No. : 292605-14-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 10 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SB-3CT purchased from MCE. Usage Cited in: Neuroscience. 2018 May 1;377:126-137.

    To confirm the critical role of MMP-2/-9 and autophagy in OGD/R induced ZO-1 redistribution and reduction, the effects of MMP-2/9 inhibitor (SB-3CT) and autophagy inhibitor (3-MA) are examined on the endothelial barrier function and ZO-1 degradation.

    SB-3CT purchased from MCE. Usage Cited in: Mol Cell Probes. 2019 Dec 28:101498.

    Expression of MMP-9 in circulating M-MDSCs from tumor bearing mice with or without stimulation of the MMP-9 inhibitor SB-3CT.
    • Biological Activity

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    • References

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    Description

    SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity[1][2][3].

    IC50 & Target[1]

    MMP-2

    13.9 nM (Ki)

    MMP-9

    600 nM (Ki)

    In Vitro

    SB-3CT has shown efficacy in an animal model of severe traumatic brain injury (TBI). SB-3CT inhibits MMP-9 with an inhibition constant Ki of 400±15 nM[1].
    Inhibition of PC3 tumor growth by SB-3CT could also be a direct consequence of reduced extracellular matrix degradation within the bone tissue by the tumor cells themselves and/or by osteoclasts. Indeed, SB-3CT treatment is associated with a reduced osteolytic response, indicating that SB-3CT helps to preserve bone integrity[3].

    In Vivo

    SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice[3].

    Animal Model: Five-week-old male C.B.-17.SCID mice[3]
    Dosage: 50 mg/kg
    Administration: IP; every other day; five weeks
    Result: Inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice.
    Molecular Weight

    306.40

    Formula

    C₁₅H₁₄O₃S₂

    CAS No.

    292605-14-2

    SMILES

    O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (163.19 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2637 mL 16.3185 mL 32.6371 mL
    5 mM 0.6527 mL 3.2637 mL 6.5274 mL
    10 mM 0.3264 mL 1.6319 mL 3.2637 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (8.16 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.35%

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    Keywords:

    SB-3CTMMPMatrix metalloproteinasesmatrixmetalloproteinaseMMP-2MMP-9gelatinasesblood-brainbarrierpermeabilityneuroprotectiveeffectsanticancerInhibitorinhibitorinhibit

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    Product Name:
    SB-3CT
    Cat. No.:
    HY-12354
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