1. Metabolic Enzyme/Protease
  2. MMP
  3. SB-3CT

SB-3CT 

Cat. No.: HY-12354 Purity: 99.59%
COA Handling Instructions

SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity.

For research use only. We do not sell to patients.

SB-3CT Chemical Structure

SB-3CT Chemical Structure

CAS No. : 292605-14-2

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 131 In-stock
Solution
10 mM * 1 mL in DMSO USD 131 In-stock
Solid
5 mg USD 119 In-stock
10 mg USD 198 In-stock
50 mg USD 495 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 18 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SB-3CT purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 Apr 10;41(4):757-775.e10.  [Abstract]

    SB-3CT (MMP9 inh.; 50 mg/kg/day; i.v.; 2 weeks) counteracts NET(neutrophil extracellular trap)-mediated EMT(epithelial-mesenchymal transition) in mice.

    SB-3CT purchased from MedChemExpress. Usage Cited in: Mol Cell Probes. 2020 Apr;50:101498.  [Abstract]

    Expression of MMP-9 in circulating M-MDSCs from tumor bearing mice with or without stimulation of the MMP-9 inhibitor SB-3CT.

    SB-3CT purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 May 1;377:126-137.  [Abstract]

    To confirm the critical role of MMP-2/-9 and autophagy in OGD/R induced ZO-1 redistribution and reduction, the effects of MMP-2/9 inhibitor (SB-3CT) and autophagy inhibitor (3-MA) are examined on the endothelial barrier function and ZO-1 degradation.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity[1][2][3].

    IC50 & Target[1]

    MMP-2

    13.9 nM (Ki)

    MMP-9

    600 nM (Ki)

    In Vitro

    SB-3CT has shown efficacy in an animal model of severe traumatic brain injury (TBI). SB-3CT inhibits MMP-9 with an inhibition constant Ki of 400±15 nM[1].
    ? Inhibition of PC3 tumor growth by SB-3CT could also be a direct consequence of reduced extracellular matrix degradation within the bone tissue by the tumor cells themselves and/or by osteoclasts. Indeed, SB-3CT treatment is associated with a reduced osteolytic response, indicating that SB-3CT helps to preserve bone integrity[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Five-week-old male C.B.-17.SCID mice[3]
    Dosage: 50 mg/kg
    Administration: IP; every other day; five weeks
    Result: Inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice.
    Molecular Weight

    306.40

    Formula

    C15H14O3S2

    CAS No.
    Appearance

    Solid

    Color

    White to pink

    SMILES

    O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 1 years; -20°C, 6 months (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (163.19 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2637 mL 16.3185 mL 32.6371 mL
    5 mM 0.6527 mL 3.2637 mL 6.5274 mL
    10 mM 0.3264 mL 1.6319 mL 3.2637 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    20% Cremophor EL    70% ddH2O

      Solubility: 5 mg/mL (16.32 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (8.16 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.59%

    References
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    • If you have published this work, please enter the PubMed ID.
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    SB-3CT Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    SB-3CT
    Cat. No.:
    HY-12354
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