2. MAPK/ERK Pathway Stem Cell/Wnt Metabolic Enzyme/Protease
  3. ERK MMP
  4. β-Neo-Endorphin

β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9.

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β-Neo-Endorphin

β-Neo-Endorphin Chemische Struktur

CAS. Nr. : 77739-21-0

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Other Forms of β-Neo-Endorphin:

β-Neo-Endorphin Related Antibodies

Top Publications Citing Use of Products

Alle ERK Isoform-spezifische Produkte anzeigen:

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ERK ERK1 ERK2 ERK5 ERK8

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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Beschreibung

β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2].

IC50 & Target

ERK1

 

ERK2

 

MMP-2

 

MMP-9

 

In Vitro

β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes[2].
β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes[2].
β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9[2].
β-Neo-Endorphin (12 h) stimulates migration in the fibroblast[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Neo-Endorphin Related Antibodies

Cell Viability Assay[2]

Cell Line: Human keratinocytes (HaCaT)
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 20 h
Result: Significantly increased the wound closure. Had no observable effect on cell viability.

Western Blot Analysis[2]

Cell Line: Human keratinocytes (HaCaT)
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 12 h
Result: Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression.
Molekulargewicht

1100.27

Formel

C54H77N13O12
CAS. Nr.
Appearance

Solid

Color

White to off-white

Sequence Shortening

YGGFLRKYP
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 100 mg/mL (90.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9089 mL 4.5443 mL 9.0887 mL
5 mM 0.1818 mL 0.9089 mL 1.8177 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9089 mL 4.5443 mL 9.0887 mL 22.7217 mL
5 mM 0.1818 mL 0.9089 mL 1.8177 mL 4.5443 mL
10 mM 0.0909 mL 0.4544 mL 0.9089 mL 2.2722 mL
15 mM 0.0606 mL 0.3030 mL 0.6059 mL 1.5148 mL
20 mM 0.0454 mL 0.2272 mL 0.4544 mL 1.1361 mL
25 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.9089 mL
30 mM 0.0303 mL 0.1515 mL 0.3030 mL 0.7574 mL
40 mM 0.0227 mL 0.1136 mL 0.2272 mL 0.5680 mL
50 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4544 mL
60 mM 0.0151 mL 0.0757 mL 0.1515 mL 0.3787 mL
80 mM 0.0114 mL 0.0568 mL 0.1136 mL 0.2840 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Neo-Endorphin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Neo-Endorphin77739-21-0ERKMMPExtracellular signal regulated kinasesMatrix metalloproteinasesmouse embryonic fibroblastsMEF cellsHuman keratinocytesHaCaTopioidpeptidewound healingInhibitorinhibitorinhibit

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