1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Bekanamycin

Bekanamycin (Synonyms: Kanamycin B)

Cat. No.: HY-B1174 Purity: >98.0%
Handling Instructions

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain.

For research use only. We do not sell to patients.

Bekanamycin Chemical Structure

Bekanamycin Chemical Structure

CAS No. : 4696-76-8

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10 mM * 1  mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain[1][2].

In Vitro

Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus[2].
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals[3].

Molecular Weight

483.51

Formula

C₁₈H₃₇N₅O₁₀

CAS No.

4696-76-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (206.82 mM)

DMSO : 1 mg/mL (2.07 mM; ultrasonic and warming and heat to 80°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0682 mL 10.3410 mL 20.6821 mL
5 mM 0.4136 mL 2.0682 mL 4.1364 mL
10 mM 0.2068 mL 1.0341 mL 2.0682 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BekanamycinKanamycin BBacterialAntibioticGram-positiveGram-negativepresynapticactioninfluxcalciumInhibitorinhibitorinhibit

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Bekanamycin
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HY-B1174
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