2. Anti-infection
  3. Antibiotic Bacterial
  4. Bekanamycin

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain.

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Bekanamycin

Bekanamycin 화학구조

CAS No. : 4696-76-8

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in Water 해외재고보유
Solid
100 mg 해외재고보유
250 mg 해외재고보유
500 mg 해외재고보유
1 g 해외재고보유
5 g   견적 받기  
10 g   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

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Other Forms of Bekanamycin:

Bekanamycin Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain[1][2].

IC50 & Target

Aminoglycoside

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 500 μg/mL
Compound: Kanamycin
Cytotoxicity against HEK293 cells measured after 24 hrs by MTT assay
Cytotoxicity against HEK293 cells measured after 24 hrs by MTT assay
[PMID: 31390524]
NIH3T3 IC50
139.6 μM
Compound: Kanamycin B
Cytotoxic activity against mouse NIH/3T3 cells after 24 hrs by MTT assay
Cytotoxic activity against mouse NIH/3T3 cells after 24 hrs by MTT assay
10.1039/C6MD00263C
NIH3T3 IC50
139.6 μM
Compound: Kanamycin B
Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay
[PMID: 24332628]
In Vitro

Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus[2].
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bekanamycin Related Antibodies
분자량

483.51

화학식

C18H37N5O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@@]3([H])O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)([H])O[C@H](CO)[C@@H](O)[C@@H]1N
Structure Classification
Initial Source

Streptomyces kanamyceticus
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

H2O : 100 mg/mL (206.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0682 mL 10.3410 mL 20.6821 mL
5 mM 0.4136 mL 2.0682 mL 4.1364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 98.0%

SDS (396 KB)

COA (253 KB) HNMR (275 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0682 mL 10.3410 mL 20.6821 mL 51.7052 mL
5 mM 0.4136 mL 2.0682 mL 4.1364 mL 10.3410 mL
10 mM 0.2068 mL 1.0341 mL 2.0682 mL 5.1705 mL
15 mM 0.1379 mL 0.6894 mL 1.3788 mL 3.4470 mL
20 mM 0.1034 mL 0.5171 mL 1.0341 mL 2.5853 mL
25 mM 0.0827 mL 0.4136 mL 0.8273 mL 2.0682 mL
30 mM 0.0689 mL 0.3447 mL 0.6894 mL 1.7235 mL
40 mM 0.0517 mL 0.2585 mL 0.5171 mL 1.2926 mL
50 mM 0.0414 mL 0.2068 mL 0.4136 mL 1.0341 mL
60 mM 0.0345 mL 0.1724 mL 0.3447 mL 0.8618 mL
80 mM 0.0259 mL 0.1293 mL 0.2585 mL 0.6463 mL
100 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.5171 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bekanamycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bekanamycin4696-76-8Kanamycin BAntibioticBacterialGram-positiveGram-negativepresynapticactioninfluxcalciumInhibitorinhibitorinhibit

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상품명:
Bekanamycin
Cat. No.:
HY-B1174
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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