2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Cefditoren Pivoxil

Cefditoren Pivoxil  (Synonyms: Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207)

Cat. No.: HY-17452A Purity: 99.29%
COA
SDS
Handling Instructions Technical Support

Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

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Cefditoren Pivoxil

Cefditoren Pivoxil 화학구조

CAS No. : 117467-28-4

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg 해외재고보유
500 mg   견적 받기  
1 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Cefditoren Pivoxil:

Cefditoren Pivoxil Related Antibodies

Top Publications Citing Use of Products

View All Beta-lactamase Isoform Specific Products:

View All Isoforms
Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections[1][2].

IC50 & Target

β-lactam

 

In Vitro

Cefditoren Pivoxil shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis[1].

Organism MIC50 (mg/L) MIC90 (mg/L) susceptible (%)
Gram-positive organisms
Streptococcus pneumoniae
(untyped)a		 0.015-0.25 0.12-1
PS ≤0.008-0.03 0.015-0.25 99-100
PI 0.06-0.5 0.25-0.5 94-100
PR 0.25-1 0.5-2 7-100
S. pyogenes ≤0.008-0.03 0.015-0.03 100
Staphylococcus aureus (MS) 0.12-0.5 0.5-1 50-100
Gram-negative organisms
Haemophilus ≤0.008-≤0.03 0.015-0.13
influenzae (untyped)b
β-Lactamase + ≤0.008-0.03 0.015-0.06 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
H. parainfluenzaeb ≤0.03 0.06
Moraxella 0.03-0.5 0.25-1 96
catarrhalis (untyped)b
β-Lactamase + ≤0.03-0.25 0.12-0.5 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
a Including PS, PI and PR strains.
b Including both β-lactamase-positive and -negative strains.
MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefditoren Pivoxil Related Antibodies
In Vivo

Pharmacokinetics in mice[1]:

Cefditoren (mg/kg) C0 (μg/ml) t1/2 (h) AUClast (μg× h/ml) Tlast (h)
6.25 53.0 0.9 30.4 6
12.5 168.4 1.1 64.1 8
25 232.5 0.9 101.3 8
50 290.6 1.1 124.4 8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

620.72

화학식

C25H28N6O7S3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N12)=C(/C=C\C3=C(C)N=CS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
용액&용해도
In Vitro: 

DMSO : ≥ 100 mg/mL (161.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6110 mL 8.0552 mL 16.1103 mL
5 mM 0.3222 mL 1.6110 mL 3.2221 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.29%

SDS (419 KB)

COA (254 KB) RP-HPLC (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6110 mL 8.0552 mL 16.1103 mL 40.2758 mL
5 mM 0.3222 mL 1.6110 mL 3.2221 mL 8.0552 mL
10 mM 0.1611 mL 0.8055 mL 1.6110 mL 4.0276 mL
15 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6851 mL
20 mM 0.0806 mL 0.4028 mL 0.8055 mL 2.0138 mL
25 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.6110 mL
30 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3425 mL
40 mM 0.0403 mL 0.2014 mL 0.4028 mL 1.0069 mL
50 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.8055 mL
60 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.6713 mL
80 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5034 mL
100 mM 0.0161 mL 0.0806 mL 0.1611 mL 0.4028 mL
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Cefditoren Pivoxil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefditoren Pivoxil117467-28-4Cefditoren pivoxyl Cefditoren pivaloyloxymethyl ester ME 1207ME1207ME 1207ME-1207Beta-lactamaseBacterialAntibioticβ-lactamasebroad-spectrum antibioticthird-generationoral cephalosporinβ lactamasesinfection diseasesInhibitorinhibitorinhibit

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상품명:
Cefditoren Pivoxil
Cat. No.:
HY-17452A
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