Cyclo(-RGDfK)

Name: Cyclo(-RGDfK)
Brand: MedChemExpress
SKU: HY-P0023
Rating: 5.0 (27 reviews)

Cat. No.: HY-P0023 Purity: 99.83%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC₅₀ of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

CAS No. : 161552-03-0

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 27 publication(s) in Google Scholar

Other Forms of Cyclo(-RGDfK):

Cyclo(-RGDfK) TFA In-stock

27 Publications Citing Use of MCE Cyclo(-RGDfK)

Bio/Physico-chemical Assay

Cell Migration/Invasion Assay

Cell Proliferation/Viability Assay

In Vivo Efficacy Study

: Cyclo(-RGDfK) purchased from MedChemExpress. Usage Cited in: Mater Today. 2026 Jan 7;92:453-472.; Cyclo(-RGDfK) (200 μM; 1 h; 37 ℃) significantly reduced intracellular fluorescence intensity, indicating that the constructed LNP-RGD nanoparticles achieved efficient and targeted cellular uptake through RGD–integrin αvβ3 interactions.

: Cyclo(-RGDfK) purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70146. [Abstract]; Integrin αVβ3 inhibitor Cyclo(-RGDfK) (10 μM) pretreatment prevented the S-EMs-induced proliferation of WKY and SHR 24 h after the application of the S-EMs.

: Cyclo(-RGDfK) purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70146. [Abstract]; Integrin αVβ3 inhibitor Cyclo(-RGDfK) (10 μM) prevented the increased ratios of P-PI3K/PI3K, P-AKT/AKT, and P-FAK/FAK in VSMCs of WKY and SHR that were promoted by S-EMs.

: Cyclo(-RGDfK) purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70146. [Abstract]; Cyclo (-RGDfK) (10 mg/kg; i.p.; every 2 d for 10 times) almost abolished vascular remodelling induced by S-EMs in the aorta of WKY mice.

: Cyclo(-RGDfK) purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Jan 7;6(7):2039-2057. [Abstract]; The integrin αvβ3 inhibitor Cyclo(-RGDfK) (20 μM; 1 h) significantly inhibited MSC migration.

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View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

αvβ3

0.94 nM (IC₅₀)

In Vitro

Cyclo(-RGDfK) is a potent and selective inhibitor of the α_vβ₃ integrin, with a IC₅₀ of 0.94 nM^[1]. [⁶⁶Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting α_vβ₃-targeted tracer accumulation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

603.67

화학식

C₂₇H₄₁N₉O₇

CAS No.

161552-03-0

Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Arg-Gly-Asp-{dPhe}-Lys)

Sequence Shortening

Cyclo(RGD-{dPhe}-K)

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 83.33 mg/mL (138.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (82.83 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6565 mL	8.2827 mL	16.5653 mL
5 mM	0.3313 mL	1.6565 mL	3.3131 mL
10 mM	0.1657 mL	0.8283 mL	1.6565 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.83%

Select Batch:

Data Sheet (280 KB) SDS (396 KB)

COA (257 KB) HNMR (346 KB) RP-HPLC (256 KB) MS (69 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)

References

[1]. Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. [Content Brief]

[2]. Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.6565 mL	8.2827 mL	16.5653 mL	41.4134 mL
	5 mM	0.3313 mL	1.6565 mL	3.3131 mL	8.2827 mL
	10 mM	0.1657 mL	0.8283 mL	1.6565 mL	4.1413 mL
	15 mM	0.1104 mL	0.5522 mL	1.1044 mL	2.7609 mL
	20 mM	0.0828 mL	0.4141 mL	0.8283 mL	2.0707 mL
	25 mM	0.0663 mL	0.3313 mL	0.6626 mL	1.6565 mL
	30 mM	0.0552 mL	0.2761 mL	0.5522 mL	1.3804 mL
	40 mM	0.0414 mL	0.2071 mL	0.4141 mL	1.0353 mL
	50 mM	0.0331 mL	0.1657 mL	0.3313 mL	0.8283 mL
	60 mM	0.0276 mL	0.1380 mL	0.2761 mL	0.6902 mL
	80 mM	0.0207 mL	0.1035 mL	0.2071 mL	0.5177 mL
DMSO	100 mM	0.0166 mL	0.0828 mL	0.1657 mL	0.4141 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cyclo(-RGDfK) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(-RGDfK)161552-03-0IntegrinMicrovasculaturecancerαvβ3 integrintumoral cellligandInhibitorinhibitorinhibit

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Cyclo(-RGDfK)

고객리뷰

Other Forms of Cyclo(-RGDfK):

Cyclo(-RGDfK) Related Antibodies

27 Publications Citing Use of MCE Cyclo(-RGDfK)

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Cyclo(-RGDfK) Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Cyclo(-RGDfK) Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report