シチシン (Synonyms: Cytisine; Sophorine; Baptitoxine; Cytisinicline)

Name: Cytisinicline
Brand: MedChemExpress
SKU: HY-N0175
Rating: 4.5 (1 reviews)

製品番号: HY-N0175 純度: 99.98%: Data Sheet SDS COA 取扱説明書
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Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs, and partial to full agonist at β4 containing receptors and α7 receptors. Has been used medically to help with smoking cessation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

シチシン 構造式

CAS 番号 : 485-35-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 26	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 26	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$24	在庫あり	Estimated Time of Arrival: December 31
10 mg	$35	在庫あり	Estimated Time of Arrival: December 31
50 mg	$70	在庫あり	Estimated Time of Arrival: December 31
100 mg	$98	在庫あり	Estimated Time of Arrival: December 31
500 mg	$196	在庫あり	Estimated Time of Arrival: December 31
1 g	$255	在庫あり	Estimated Time of Arrival: December 31
5 g	$434	在庫あり	Estimated Time of Arrival: December 31
10 g	$565	在庫あり	Estimated Time of Arrival: December 31
25 g	$848	在庫あり	Estimated Time of Arrival: December 31
50 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Cytisinicline:

Cytisine-d₄ 在庫あり
Cytisinicline (Standard) 在庫あり

顧客検証

•J Ethnopharmacol. 2022 Mar 1:285:114796. [Abstract]

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•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs^[1], and partial to full agonist at β4 containing receptors and α7 receptors^[2]. Has been used medically to help with smoking cessation^[3].

IC₅₀ & Target

α4β2 nAChRs^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	CC₅₀	> 80 μM Compound: 5	Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	[PMID: 25147619]
MDCK	EC₅₀	> 80 μM Compound: 5	Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytocidal activity after 48 hrs by CellTiter-Glo assay Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytocidal activity after 48 hrs by CellTiter-Glo assay	[PMID: 25147619]
Oocyte	EC₅₀	0.9 μM Compound: 5	Effective concentration against Nicotinic acetylcholine receptor alpha4-beta4 expressed in xenopus oocytes Effective concentration against Nicotinic acetylcholine receptor alpha4-beta4 expressed in xenopus oocytes	[PMID: 16033252]
Oocyte	EC₅₀	2.7 μM Compound: 5	Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes	[PMID: 16033252]
Oocyte	EC₅₀	39 μM Compound: 5	Effective concentration against Nicotinic acetylcholine receptor alpha2-beta4 expressed in xenopus oocytes Effective concentration against Nicotinic acetylcholine receptor alpha2-beta4 expressed in xenopus oocytes	[PMID: 16033252]
Oocyte	EC₅₀	67 μM Compound: 5	Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes	[PMID: 16033252]
Oocyte	EC₅₀	71 μM Compound: 5	Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytes Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytes	[PMID: 16033252]
Oocyte	EC₅₀	72 μM Compound: 5	Effective concentration against Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes Effective concentration against Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes	[PMID: 16033252]
PC-12	EC₅₀	10 μM Compound: 7	Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic) Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)	[PMID: 9435889]
TE-671	EC₅₀	11 nM Compound: Cytisine (1)	Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors	[PMID: 15686946]

体外実験

Cytisinicline (Cytisine) (2.5, 5 and 10 mM) is capable of inducing apoptosis in HepG2 cells^[4].
Treatment with Cytisinicline (Cytisine) increases the percentage of cells in the sub-G₁ phase (P<0.01). The preincubation of HepG2 cells with Cytisinicline (Cytisine) (2.5, 5 and 10 mM) significantly increases the sub-G₁ cell population^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Cytisinicline (Cytisine) (5 mg/kg, i.p.) eat less and gain less weight than those that receive the vehicle^[2].
Total pellet intake increases during Cytisinicline (Cytisine) substitution relative to nicotine and animals self-administered Cytisine significantly less than nicotine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

190.25

分子式

C₁₁H₁₄N₂O

CAS 番号

485-35-8

Appearance

Solid

Color

White to light yellow

SMILES

O=C1N(C[C@@]2([H])C[C@]3([H])CNC2)C3=CC=C1

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : ≥ 100 mg/mL (525.64 mM)

DMSO : 100 mg/mL (525.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2564 mL	26.2818 mL	52.5635 mL
5 mM	1.0513 mL	5.2564 mL	10.5127 mL
10 mM	0.5256 mL	2.6282 mL	5.2564 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.98%

Select Batch:

データシート (279 KB) SDS (420 KB)

COA (253 KB) HNMR (158 KB) RP-HPLC (207 KB) MS (228 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Pabreza LA, et al. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991 Jan;39(1):9-12. [Content Brief]

[2]. Grebenstein PE, et al. The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2013 Sep;110:192-200. [Content Brief]

[3]. Walker N, et al. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014 Dec 18;371(25):2353-62. [Content Brief]

[4]. Yu L, et al. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018 Mar;39(3):1475-1484. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	5.2564 mL	26.2818 mL	52.5635 mL	131.4088 mL
	5 mM	1.0513 mL	5.2564 mL	10.5127 mL	26.2818 mL
	10 mM	0.5256 mL	2.6282 mL	5.2564 mL	13.1409 mL
	15 mM	0.3504 mL	1.7521 mL	3.5042 mL	8.7606 mL
	20 mM	0.2628 mL	1.3141 mL	2.6282 mL	6.5704 mL
	25 mM	0.2103 mL	1.0513 mL	2.1025 mL	5.2564 mL
	30 mM	0.1752 mL	0.8761 mL	1.7521 mL	4.3803 mL
	40 mM	0.1314 mL	0.6570 mL	1.3141 mL	3.2852 mL
	50 mM	0.1051 mL	0.5256 mL	1.0513 mL	2.6282 mL
	60 mM	0.0876 mL	0.4380 mL	0.8761 mL	2.1901 mL
	80 mM	0.0657 mL	0.3285 mL	0.6570 mL	1.6426 mL
	100 mM	0.0526 mL	0.2628 mL	0.5256 mL	1.3141 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cytisinicline Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytisinicline485-35-8Cytisine Sophorine BaptitoxinenAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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シチシン (Synonyms: Cytisine; Sophorine; Baptitoxine; Cytisinicline)

カスタマーレビュー

Other Forms of Cytisinicline:

シチシン 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

シチシン 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Cytisinicline Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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Request for HNMR Report

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シチシン関連抗体

シチシン関連抗体