D-Erythro-dihydrosphingosine (Synonyms: D-エリトロ-スフィンガニン; D-スフィンゴシン)

Name: D-Erythro-dihydrosphingosine
Brand: MedChemExpress
SKU: HY-W019838
Rating: 4.5 (1 reviews)

製品番号: HY-W019838 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

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D-Erythro-dihydrosphingosine 構造式

CAS 番号 : 764-22-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$60	在庫あり	Estimated Time of Arrival: December 31
10 mg	$100	在庫あり	Estimated Time of Arrival: December 31
25 mg	$220	在庫あり	Estimated Time of Arrival: December 31
50 mg	$360	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of D-Erythro-dihydrosphingosine:

D-Erythro-dihydrosphingosine-d₇ 在庫あり
D-Erythro-dihydrosphingosine (Standard) お問い合わせ

顧客検証

•Cell Host Microbe. 2026 Mar 11;34(3):460-478.e9. [Abstract]

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

Phospholipase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Phospholipase A PLD Phospholipase C

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
FL5.12	IC₅₀	3.5 μM Compound: 7	Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis	[PMID: 27475534]
HBL-100	GI₅₀	25 μM Compound: 10d	Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
HeLa	GI₅₀	15 μM Compound: 10d	Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
Jurkat	IC₅₀	3.53 μM Compound: Dihydrosphingosine	Inhibition of wild type human Jurkat cells after 18 hrs by MTT assay Inhibition of wild type human Jurkat cells after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	3.68 μM Compound: Dihydrosphingosine	Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	4.9 μM Compound: Dihydrosphingosine	Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells proliferation after 18 hrs by MTT assay Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR1 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
Jurkat	IC₅₀	6.31 μM Compound: Dihydrosphingosine	Inhibition of human 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells proliferation after 18 hrs by MTT assay Inhibition of human 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR3 mutant cells proliferation after 18 hrs by MTT assay	[PMID: 17400555]
SW1573	GI₅₀	4.5 μM Compound: 10d	Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
T47D	GI₅₀	22 μM Compound: 10d	Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay	[PMID: 25899335]
WiDr	GI₅₀	19 μM Compound: 10d	Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay	[PMID: 25899335]

体外実験

D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na₃VO₄-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [³H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA₂α activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

301.51

分子式

C₁₈H₃₉NO₂

CAS 番号

764-22-7

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO

Structure Classification

Others

Initial Source

Endogenous metabolite

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

Ethanol : 50 mg/mL (165.83 mM; Need ultrasonic)

DMSO : 10 mg/mL (33.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3166 mL	16.5832 mL	33.1664 mL
5 mM	0.6633 mL	3.3166 mL	6.6333 mL
10 mM	0.3317 mL	1.6583 mL	3.3166 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 3

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 4

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 5

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.55%

Select Batch:

データシート (267 KB) SDS (393 KB)

COA (239 KB) LCMS (288 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	3.3166 mL	16.5832 mL	33.1664 mL	82.9160 mL
	5 mM	0.6633 mL	3.3166 mL	6.6333 mL	16.5832 mL
	10 mM	0.3317 mL	1.6583 mL	3.3166 mL	8.2916 mL
	15 mM	0.2211 mL	1.1055 mL	2.2111 mL	5.5277 mL
	20 mM	0.1658 mL	0.8292 mL	1.6583 mL	4.1458 mL
	25 mM	0.1327 mL	0.6633 mL	1.3267 mL	3.3166 mL
	30 mM	0.1106 mL	0.5528 mL	1.1055 mL	2.7639 mL
Ethanol	40 mM	0.0829 mL	0.4146 mL	0.8292 mL	2.0729 mL
	50 mM	0.0663 mL	0.3317 mL	0.6633 mL	1.6583 mL
	60 mM	0.0553 mL	0.2764 mL	0.5528 mL	1.3819 mL
	80 mM	0.0415 mL	0.2073 mL	0.4146 mL	1.0364 mL
	100 mM	0.0332 mL	0.1658 mL	0.3317 mL	0.8292 mL

D-Erythro-dihydrosphingosine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Erythro-dihydrosphingosine764-22-7Sphinganine (d18:0)Endogenous MetabolitePhospholipaseInhibitorinhibitorinhibit

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D-Erythro-dihydrosphingosine (Synonyms: D-エリトロ-スフィンガニン; D-スフィンゴシン)

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Other Forms of D-Erythro-dihydrosphingosine:

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

D-Erythro-dihydrosphingosine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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D-Erythro-dihydrosphingosine (Synonyms: D-エリトロ-スフィンガニン; D-スフィンゴシン)

カスタマーレビュー

Other Forms of D-Erythro-dihydrosphingosine:

D-Erythro-dihydrosphingosine 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

Phospholipase アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

D-Erythro-dihydrosphingosine 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

D-Erythro-dihydrosphingosine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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