2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Dopamine Receptor Apoptosis
  4. Fenoldopam mesylate

Fenoldopam (mesylate)  (Synonyms: Fenoldopam (methanesulfonate); メシル酸フェノルドパム; SKF-82526 (mesylate))

製品番号: HY-B0735A 純度: 99.94%
COA 取扱説明書 Technical Support

Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis.

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Fenoldopam mesylate

Fenoldopam (mesylate) 構造式

CAS 番号 : 67227-57-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 38 在庫あり
Solution
10 mM * 1 mL in DMSO USD 38 在庫あり
Solid
5 mg $35 在庫あり
10 mg $55 在庫あり
25 mg $116 在庫あり
50 mg $187 在庫あり
100 mg $286 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Based on 4 publication(s) in Google Scholar

Other Forms of Fenoldopam mesylate:

Fenoldopam (mesylate) 関連抗体

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製品説明

Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].

IC50 & Target

IC50: 0.8974 μM (LSD1)[2]
体外実験

Fenoldopam is a partial agonist with low efficacy at DA1 receptors linked to cAMP generation in the LLC-PK1 cells[1].
Fenoldopam (0-300 μM; 48 or 72 h) displays significant antiproliferative activity against RCC cell lines[2].
Fenoldopam (5 μM and 10 μM; 72 h) induces cell apoptosis in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fenoldopam (mesylate) 関連抗体

Cell Proliferation Assay[1]

Cell Line: 786-O, ACHN, and HK-2 cells
Concentration: 0-300 μM
Incubation Time: 48 or 72 hours
Result: Inhibited the growth of ACHN cells (IC50=16.55 μM, 48 h; IC50=10.34 μM, 72 h), 786-O cells (IC50=57.89 μM, 48 h; IC50=47.52 μM, 72 h), and HK2 cells (IC50>300 μM, 48h and 72 h).

Apoptosis Analysis[1]

Cell Line: ACHN cells
Concentration: 5 μM and 10 μM
Incubation Time: 72 hours
Result: Increased apoptotic cells from at 2.2% (control) to 47.7% (5 μM, fenoldopam) and 60.8% (10 μM, fenoldopam), respectively.
体内実験

Fenoldopam mesylate (subcutaneous injection; 100 mg/kg; once daily; 2 d) can induce arteritis in rats detected by magnetic resonance imaging (MRI)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats[3]
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 100 mg/kg; once daily; 2 days
Result: Showed low-intensity areas and a high signal intensity region around the artery, and these findings were considered to be erythrocytes infiltrating the arterial wall and perivascular edema, respectively.
Observed perivascular edema histopathologically.
分子量

401.86

分子式

C17H20ClNO6S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : ≥ 36 mg/mL (89.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (24.88 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4884 mL 12.4421 mL 24.8843 mL
5 mM 0.4977 mL 2.4884 mL 4.9769 mL
10 mM 0.2488 mL 1.2442 mL 2.4884 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.94%

COA (251 KB) HNMR (270 KB) LCMS (88 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.4884 mL 12.4421 mL 24.8843 mL 62.2107 mL
5 mM 0.4977 mL 2.4884 mL 4.9769 mL 12.4421 mL
10 mM 0.2488 mL 1.2442 mL 2.4884 mL 6.2211 mL
15 mM 0.1659 mL 0.8295 mL 1.6590 mL 4.1474 mL
20 mM 0.1244 mL 0.6221 mL 1.2442 mL 3.1105 mL
DMSO 25 mM 0.0995 mL 0.4977 mL 0.9954 mL 2.4884 mL
30 mM 0.0829 mL 0.4147 mL 0.8295 mL 2.0737 mL
40 mM 0.0622 mL 0.3111 mL 0.6221 mL 1.5553 mL
50 mM 0.0498 mL 0.2488 mL 0.4977 mL 1.2442 mL
60 mM 0.0415 mL 0.2074 mL 0.4147 mL 1.0368 mL
80 mM 0.0311 mL 0.1555 mL 0.3111 mL 0.7776 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fenoldopam mesylate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenoldopam67227-57-0SKF-82526SKF82526SKF 82526Dopamine ReceptorApoptosislysine-specific demethylase 1 inhibitoranti-hypertensive activityanti-proliferation activity786-OACHNHK-2LLC-PK1Inhibitorinhibitorinhibit

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製品名:
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製品番号:
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