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  4. Ammonium glycyrrhizinate

グリチルリチン酸一アンモニウム  (Synonyms: Monoammonium glycyrrhizinate; Ammonium glycyrrhizinate; Glycyrrhizic acid (ammonium salt); Ammonium glycyrrhizate)

製品番号: HY-76225 純度: 95.68%
COA 取扱説明書 Technical Support

Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.

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CAS 番号 : 53956-04-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
50 mg $50 在庫あり
100 mg $80 在庫あり
500 mg $240 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 59 publication(s) in Google Scholar

Other Forms of Ammonium glycyrrhizinate:

グリチルリチン酸一アンモニウム 関連抗体

Top Publications Citing Use of Products

顧客検証

In Vivo Efficacy Study
WB
Histological Imaging/Staining
RT-PCR

    Ammonium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Chem Eng J. 2025 May 1.

    The protein expression of P21, P16, Tom20, HMGB1, cGAS, and STING were assessed via western blotting with β-tubulin as a loading control. Data were expressed as mean ± SEM (n = 3). The results showed that Glycyrrhizic acid (10 μM; 24 h) significantly enhanced the anti-senescent effect of exosomes and inhibited the HMGB1/cGAS-STING axis.

    Ammonium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Apr 4;43(1):105.  [Abstract]

    Glycyrrhizin (1 nM/kg; i.c.v.; administered every 3 days starting from day 14 after modeling). A, In a subcutaneous xenograft tumor model, the tumor volumes were measured and monitored every 7 days from each group of mice. (n = 4/group). B, The pictures of corresponding subcutaneous xenograft tumors dissected from each group mice at 42 days post-injection. C Tumor weights from each group at 42 days post-injection.

    Ammonium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec:135:156059.  [Abstract]

    qRT-PCR analysis of HSP90AB1 and HSP90AA1 in NOK cells after stimulation with LPS and HCQ (10 µM) or Glycyrrhiz (GL, 100 μg/mL) in for 24 h.

    Ammonium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Adv Healthc Mater. 2024 Jan;13(2):e2301808.  [Abstract]

    Osteoinduction was hindered in Glycyrrhizic acid (GA, 10 mM; 30min) group.

    Ammonium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2020 Jun;53(6):e12829.  [Abstract]

    Protein levels of pro-caspase-1 + p10 + p12, GADMD, IL-1β, IL-18 and NLRP3 are detected by Western blotting. Glycyrrhizin inhibits pyroptosis in TNF-α-induced M1 macrophages.

    Interleukin Related アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

    • 生物活性

    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.

    体内実験

    The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and 30 mg/kg) administration. Pretreatment with MAG (10 and 30 mg/kg) efficiently reduces the production of TNF-α and IL-1β. MAG (10, 30 mg/kg) significantly decreases NF-κB p65 protein expression, compared with LPS. On the contrary, LPS significantly reduces IκB-α protein expression compared with the control group, whereas MAG (10 and 30 mg/kg) significantly increased I B- expression, compared with the LPS group[1].
    Low- and high-dose MAG treatment significantly reduces the AST, ALT, TBIL, and TBA levels at 14 and 21 d time points when compared with that of the RIF and INH group, suggesting the protective effect of MAG on RIF- and INH-induced liver injury. MAG treatment groups elevate the hepatic GSH level at 7, 14, and 21 d time points and markedly reduce the MDA level at 14 and 21 d time points in RIF- and INH-treated rats, suggesting the protective effect of MAG in RIF- and INH induced liver injuries[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    839.96

    分子式

    C42H65NO16
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1[C@]([C@](CC2)(C)[C@@]3(C)C([C@]([C@@]4(C)CC3)([H])C[C@@](CC4)(C)C(O)=O)=C1)([H])[C@](CC5)(C)[C@]2([H])C([C@H]5O[C@@H](O[C@H](C(O)=O)[C@H]6O)[C@H](O[C@@H]([C@H](O)[C@@H](O)[C@@H]7O)O[C@@H]7C(O)=O)[C@H]6O)(C)C.N
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (119.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1905 mL 5.9527 mL 11.9053 mL
    5 mM 0.2381 mL 1.1905 mL 2.3811 mL
    10 mM 0.1191 mL 0.5953 mL 1.1905 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体積 （開始）

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    濃度 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (2.98 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.98 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    % 
    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 95.68%

    COA (258 KB) RP-HPLC (248 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [1][2]

    Mice[1]
    In this study, BALB/c mice (male, 6-8 weeks old, and 20-25 g) are used. Mice are randomly divided into five groups: control group, LPS group, and LPS + Monoammonium glycyrrhizinate (MAG: 3, 10, and 30 mg/kg) groups. Each group contains eight mice. Mice are anesthetized with intraperitoneal injection of sodium pentobarbital (50 mg/kg). Before inducing acute lung injury, the mice are given intraperitoneal injection with MAG (3, 10, and 30 mg/kg). One hour later, LPS (5 mg/kg) is instilled intratracheally to induce acute lung injury. Normal mice are given PBS[1].
    Rats[2]
    Male Wistar rats (180-220 g) are used. Rats are randomly divided into four groups, i.e., control group, RIF and INH group, MAG low-dose group, and MAG high-dose group, each group has 15 rats. Rats in the RIF and INH group receive RIF (60 mg/kg) and INH (60 mg/kg) by gavage administration once daily; rats in MAG groups are pretreated with MAG at the doses of 45 or 90 mg/kg, RIF (60 mg/kg) and INH (60 mg/kg) are given 3 h after MAG administration; rats in the control group are treated with saline. To evaluate the dynamic effect of drugs, rats in each group are sacrificed on 7, 14, and 21 d after drug administration[2].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.1905 mL 5.9527 mL 11.9053 mL 29.7633 mL
    5 mM 0.2381 mL 1.1905 mL 2.3811 mL 5.9527 mL
    10 mM 0.1191 mL 0.5953 mL 1.1905 mL 2.9763 mL
    15 mM 0.0794 mL 0.3968 mL 0.7937 mL 1.9842 mL
    20 mM 0.0595 mL 0.2976 mL 0.5953 mL 1.4882 mL
    25 mM 0.0476 mL 0.2381 mL 0.4762 mL 1.1905 mL
    30 mM 0.0397 mL 0.1984 mL 0.3968 mL 0.9921 mL
    40 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7441 mL
    50 mM 0.0238 mL 0.1191 mL 0.2381 mL 0.5953 mL
    60 mM 0.0198 mL 0.0992 mL 0.1984 mL 0.4961 mL
    80 mM 0.0149 mL 0.0744 mL 0.1488 mL 0.3720 mL
    100 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2976 mL
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    Ammonium glycyrrhizinate Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ammonium glycyrrhizinate53956-04-0Monoammonium glycyrrhizinateGlycyrrhizic acid Ammonium glycyrrhizateEnvironmental PollutantsInterleukin RelatedEnvironmental ContaminantsILInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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