Nitrofurantoin (Synonyms: ニトロフラントイン)

Name: Nitrofurantoin
Brand: MedChemExpress
SKU: HY-A0090
Rating: 5.0 (10 reviews)

製品番号: HY-A0090 純度: 99.71%: Data Sheet SDS COA 取扱説明書
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Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Nitrofurantoin 構造式

CAS 番号 : 67-20-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solid
500 mg	$55	在庫あり	Estimated Time of Arrival: December 31
1 g	$66	在庫あり	Estimated Time of Arrival: December 31
5 g	$106	在庫あり	Estimated Time of Arrival: December 31
10 g		お問い合わせ
50 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Other Forms of Nitrofurantoin:

Nitrofurantoin (Standard) 在庫あり
Nitrofurantoin-¹³C₃ お問い合わせ
Nitrofurantoin sodium お問い合わせ

顧客検証

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

β-lactam

Cellular Effect

Cell Line	Type	Value	Description	References
5637	IC₅₀	21.3 3 Compound: NF	Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay	[PMID: 18187237]
5637	IC₅₀	21.3 3 Compound: NF	Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay	[PMID: 18187237]
5637	IC₅₀	21.3 3 Compound: NF	Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay	[PMID: 18187237]
A-427	IC₅₀	1.86 3 Compound: NF	Cytotoxicity against human A427 cells after 96 hrs by microtiter assay Cytotoxicity against human A427 cells after 96 hrs by microtiter assay	[PMID: 18187237]
A-427	IC₅₀	1.86 3 Compound: NF	Cytotoxicity against human A427 cells after 96 hrs by microtiter assay Cytotoxicity against human A427 cells after 96 hrs by microtiter assay	[PMID: 18187237]
A-427	IC₅₀	1.86 3 Compound: NF	Cytotoxicity against human A427 cells after 96 hrs by microtiter assay Cytotoxicity against human A427 cells after 96 hrs by microtiter assay	[PMID: 18187237]
DAN-G	IC₅₀	6.74 3 Compound: NF	Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay	[PMID: 18187237]
Vero	IC₅₀	0.9 1 Compound: Nitrofuradantoin	Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay	[PMID: 10464017]
Caco-2	IC₅₀	0.115 3 Compound: NF	Anticancer activity against human Caco-2 cells incubated for 72 hrs by MTT assay Anticancer activity against human Caco-2 cells incubated for 72 hrs by MTT assay	[PMID: 36921275]
FHC	CC₅₀	> 100 3 Compound: Nft	Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay	[PMID: 33007545]
DAN-G	IC₅₀	6.74 3 Compound: NF	Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay	[PMID: 18187237]
KYSE-510	IC₅₀	29 3 Compound: NF	Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay	[PMID: 18187237]
FHC	CC₅₀	>100 3 Compound: Nft	Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay	[PMID: 33007545]
KYSE-70 cell line	IC₅₀	22.8 3 Compound: NF	Cytotoxicity against human KYSE70 cells after 96 hrs by microtiter assay Cytotoxicity against human KYSE70 cells after 96 hrs by microtiter assay	[PMID: 18187237]
LCLC-103H cell line	IC₅₀	2.34 3 Compound: NF	Cytotoxicity against human LCLC-103H cells after 96 hrs by microtiter assay Cytotoxicity against human LCLC-103H cells after 96 hrs by microtiter assay	[PMID: 18187237]
HeLa	IC₅₀	0.166 3 Compound: NF	Anticancer activity against human HeLa cells incubated for 72 hrs by MTT assay Anticancer activity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 36921275]
KYSE-510	IC₅₀	29 3 Compound: NF	Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay	[PMID: 18187237]
MCF7	IC₅₀	4.44 3 Compound: NF	Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay	[PMID: 18187237]
KYSE-70 cell line	IC₅₀	22.8 3 Compound: NF	Cytotoxicity against human KYSE70 cells after 96 hrs by microtiter assay Cytotoxicity against human KYSE70 cells after 96 hrs by microtiter assay	[PMID: 18187237]
RT-4	IC₅₀	7 3 Compound: NF	Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay	[PMID: 18187237]
LCLC-103H cell line	IC₅₀	2.34 3 Compound: NF	Cytotoxicity against human LCLC-103H cells after 96 hrs by microtiter assay Cytotoxicity against human LCLC-103H cells after 96 hrs by microtiter assay	[PMID: 18187237]
SISO	IC₅₀	7.27 3 Compound: NF	Cytotoxicity against human SISO cells after 96 hrs by microtiter assay Cytotoxicity against human SISO cells after 96 hrs by microtiter assay	[PMID: 18187237]
Vero	IC₅₀	0.9 1 Compound: Nitrofuradantoin	Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay	[PMID: 10464017]
MCF7	IC₅₀	4.44 3 Compound: NF	Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay	[PMID: 18187237]
Caco-2	IC₅₀	0.115 3 Compound: NF	Anticancer activity against human Caco-2 cells incubated for 72 hrs by MTT assay Anticancer activity against human Caco-2 cells incubated for 72 hrs by MTT assay	[PMID: 36921275]
Vero	CC₅₀	23 6 Compound: nitrofurantoin	Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay	[PMID: 22691154]
RT-4	IC₅₀	7 3 Compound: NF	Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay	[PMID: 18187237]
Sf21	IC₅₀	>1 2 Compound: Nitrofurantoin	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
SISO	IC₅₀	7.27 3 Compound: NF	Cytotoxicity against human SISO cells after 96 hrs by microtiter assay Cytotoxicity against human SISO cells after 96 hrs by microtiter assay	[PMID: 18187237]
THP-1	IC₅₀	>100 3 Compound: NFT	Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay	[PMID: 36516584]
Vero	CC₅₀	23 6 Compound: nitrofurantoin	Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay	[PMID: 22691154]
Vero	IC₅₀	>100 3 Compound: NFT	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay	[PMID: 36516584]
WI-38	IC₅₀	0.162 3 Compound: NF	Cytotoxicity in human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36921275]
DAN-G	IC₅₀	6.74 3 Compound: NF	Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay	[PMID: 18187237]
FHC	CC₅₀	> 100 3 Compound: Nft	Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay	[PMID: 33007545]
HeLa	IC₅₀	0.166 3 Compound: NF	Anticancer activity against human HeLa cells incubated for 72 hrs by MTT assay Anticancer activity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 36921275]
KYSE-510	IC₅₀	29 3 Compound: NF	Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay	[PMID: 18187237]
MCF7	IC₅₀	4.44 3 Compound: NF	Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay	[PMID: 18187237]
RT-4	IC₅₀	7 3 Compound: NF	Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay	[PMID: 18187237]
SISO	IC₅₀	7.27 3 Compound: NF	Cytotoxicity against human SISO cells after 96 hrs by microtiter assay Cytotoxicity against human SISO cells after 96 hrs by microtiter assay	[PMID: 18187237]
Sf21	IC₅₀	> 1000 3 Compound: Nitrofurantoin	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	> 1000 3 Compound: Nitrofurantoin	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
THP-1	IC₅₀	> 100 3 Compound: NFT	Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay	[PMID: 36516584]
Vero	CC₅₀	23 6 Compound: nitrofurantoin	Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay	[PMID: 22691154]
Vero	IC₅₀	0.9 1 Compound: Nitrofuradantoin	Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay	[PMID: 10464017]
Vero	IC₅₀	> 100 3 Compound: NFT	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay	[PMID: 36516584]
WI-38	IC₅₀	0.162 3 Compound: NF	Cytotoxicity in human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36921275]

体外実験

Nitrofurantoin (0-512 mg/L; 8 h) treatment inhibits the growth of E. coli isolates^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	E. coli isolates: DA10708, DA13815, DA13824, DA13957, DA13992, DA10626, DA10627
Concentration:	0, 32, 64, 128, 256, and 512 mg/L
Incubation Time:	8 hours
Result:	Observed bactericidal effect at 32 mg/L For DA10708, DA13815 and DA13824. Inhibited the growth of DA13957 and DA13992 completely at 128 mg/L, observed bactericidal effect at 256 mg/L. Showed a moderate killing at >128 mg/L for DA10626 and DA10627.

体内実験

1.19 Nitrofurantoin pharmacokinetic effects in SD Rats^[4].

Parameters	10 mg/kg p.o.	2 mg/kg i.v.
AUC_0-720 (μg/mL·min)	306
AUC_0-120 (μg/mL·min)		90.3
AUC_0-∞ (μg/mL·min)	344	91.5
C_max (μg/mL)	1.01
CL/F or CL (ml/min/kg)	31.0	22.7
t_1/2 (min)	166	23.6
Bioavailability (%)	60.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

238.16

分子式

C₈H₆N₄O₅

CAS 番号

67-20-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC(CN1/N=C/C2=CC=C([N+]([O-])=O)O2)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (419.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1989 mL	20.9943 mL	41.9886 mL
5 mM	0.8398 mL	4.1989 mL	8.3977 mL
10 mM	0.4199 mL	2.0994 mL	4.1989 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.71%

Select Batch:

データシート (278 KB) SDS (419 KB)

COA (248 KB) HNMR (146 KB) RP-HPLC (244 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Huttner A, et al. Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials. J Antimicrob Chemother. 2015 Sep;70(9):2456-64. [Content Brief]

[2]. Garau J. Other antimicrobials of interest in the era of extended-spectrum beta-lactamases: fosfomycin, nitrofurantoin and tigecycline. Clin Microbiol Infect. 2008 Jan;14 Suppl 1:198-202. [Content Brief]

[3]. Linus Sandegren, et al. Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli. J Antimicrob Chemother. 2008 Sep;62(3):495-503. [Content Brief]

[4]. Xiaodong Wang, et al. Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos. 2007 Feb;35(2):268-74. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1989 mL	20.9943 mL	41.9886 mL	104.9714 mL
	5 mM	0.8398 mL	4.1989 mL	8.3977 mL	20.9943 mL
	10 mM	0.4199 mL	2.0994 mL	4.1989 mL	10.4971 mL
	15 mM	0.2799 mL	1.3996 mL	2.7992 mL	6.9981 mL
	20 mM	0.2099 mL	1.0497 mL	2.0994 mL	5.2486 mL
	25 mM	0.1680 mL	0.8398 mL	1.6795 mL	4.1989 mL
	30 mM	0.1400 mL	0.6998 mL	1.3996 mL	3.4990 mL
	40 mM	0.1050 mL	0.5249 mL	1.0497 mL	2.6243 mL
	50 mM	0.0840 mL	0.4199 mL	0.8398 mL	2.0994 mL
	60 mM	0.0700 mL	0.3499 mL	0.6998 mL	1.7495 mL
	80 mM	0.0525 mL	0.2624 mL	0.5249 mL	1.3121 mL
	100 mM	0.0420 mL	0.2099 mL	0.4199 mL	1.0497 mL

Nitrofurantoin Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitrofurantoin67-20-9BacterialAntibioticantimicrobialantibioticurinary tractinfectionUTIcystitiskidneyE. coliInhibitorinhibitorinhibit

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Nitrofurantoin (Synonyms: ニトロフラントイン)

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Other Forms of Nitrofurantoin:

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Complete Stock Solution Preparation Table

Nitrofurantoin Related Classifications

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The molarity calculator equation

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Nitrofurantoin (Synonyms: ニトロフラントイン)

カスタマーレビュー

Other Forms of Nitrofurantoin:

Nitrofurantoin 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Antibiotic アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Nitrofurantoin 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Nitrofurantoin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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