2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Antibiotic DNA/RNA Synthesis
  4. Oxolinic acid

オキソリン酸  (Synonyms: Oxolinic acid)

製品番号: HY-B1002 純度: 98.97%
COA 取扱説明書 Technical Support

Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice.

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Oxolinic acid

オキソリン酸 構造式

CAS 番号 : 14698-29-4

容量 価格（税別） 在庫状況 数量
500 mg $30 在庫あり
1 g $40 在庫あり
5 g $80 在庫あり
10 g $130 在庫あり
25 g $300 在庫あり
50 g $420 在庫あり
> 100 g   お問い合わせ  

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Based on 3 publication(s) in Google Scholar

Other Forms of Oxolinic acid:

オキソリン酸 関連抗体

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Antibiotic アイソフォーム固有の製品をすべて表示:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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すべてのアイソフォームを表示
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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製品説明

Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

IC50 & Target

Antimicrobial[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
0.81 μM
Compound: 1
Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs
Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs
[PMID: 31299492]
体外実験

Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli[1].
Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis [1].
Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis[1].
Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747[2].
Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

オキソリン酸 関連抗体
体内実験

Oxolinic acid (32 mg/kg; i.p.) induces hyperactivity in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino CD1 mice (22-25 g)[3]
Dosage: 16 mg/kg, 32 mg/kg, 64 mg/kg, 128 mg/kg
Administration: Intraperitoneal injection
Result: Stimulated the horizontal activity of mice, culminated at the 32 mg/kg dose but disappeared at the highest tested dose, 128 mg/kg.
分子量

261.23

分子式

C13H11NO5
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

0.5 M NaOH : ≥ 50 mg/mL (191.40 mM)

DMSO : 1 mg/mL (3.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8280 mL 19.1402 mL 38.2804 mL
5 mM 0.7656 mL 3.8280 mL 7.6561 mL
10 mM 0.3828 mL 1.9140 mL 3.8280 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 98.97%

COA (250 KB) LCMS (107 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 0.5 M NaOH 1 mM 3.8280 mL 19.1402 mL 38.2804 mL 95.7011 mL
0.5 M NaOH 5 mM 0.7656 mL 3.8280 mL 7.6561 mL 19.1402 mL
10 mM 0.3828 mL 1.9140 mL 3.8280 mL 9.5701 mL
15 mM 0.2552 mL 1.2760 mL 2.5520 mL 6.3801 mL
20 mM 0.1914 mL 0.9570 mL 1.9140 mL 4.7851 mL
25 mM 0.1531 mL 0.7656 mL 1.5312 mL 3.8280 mL
30 mM 0.1276 mL 0.6380 mL 1.2760 mL 3.1900 mL
40 mM 0.0957 mL 0.4785 mL 0.9570 mL 2.3925 mL
50 mM 0.0766 mL 0.3828 mL 0.7656 mL 1.9140 mL
60 mM 0.0638 mL 0.3190 mL 0.6380 mL 1.5950 mL
80 mM 0.0479 mL 0.2393 mL 0.4785 mL 1.1963 mL
100 mM 0.0383 mL 0.1914 mL 0.3828 mL 0.9570 mL
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Oxolinic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxolinic acid14698-29-4BacterialAntibioticDNA/RNA SynthesisantimicrobialantibioticurinarytractinfectionsDNA/RNAsynthesisdopamineuptakeInhibitorinhibitorinhibit

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