2. Anti-infection
  3. Bacterial Antibiotic
  4. Sisomicin sulfate

Sisomicin (sulfate)  (Synonyms: シソマイシン 硫酸塩)

製品番号: HY-B1222 純度: 99.29%
COA 取扱説明書 Technical Support

Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.

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Sisomicin sulfate

Sisomicin (sulfate) 構造式

CAS 番号 : 53179-09-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in Water USD 55 在庫あり
Solid
100 mg $50 在庫あり
250 mg $90 在庫あり
500 mg $145 在庫あり
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5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 5 publication(s) in Google Scholar

Other Forms of Sisomicin sulfate:

Sisomicin (sulfate) 関連抗体

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Antibiotic アイソフォーム固有の製品をすべて表示:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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  • 純度とドキュメンテーション

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製品説明

Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.

IC50 & Target

Aminoglycoside

 

体外実験

Sisomicin sulfate (6.25 μg/mL) completely inhibits the growth of various clinical isolates bacterial, such as Klebsiella, Salmonella, Citrobacter, and Staphylococcus aureus[1].
Sisomicin sulfate (20 μg/mL; 30 min) has insignificant impairment on polymorphonuclear neutrophil (PMN)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sisomicin (sulfate) 関連抗体
体内実験

Sisomicin sulfate (4 mg/kg; ip; single dose) appears to accumulate and persist in the kidneys, showing potential renal toxicity in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

692.72

分子式

C19H37N5O7 . 5/2 H2SO4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H]2O)([H])OC(CN)=CC1.[2.5H2SO4]
Structure Classification
Initial Source

Micromonospora inyoensis
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 125 mg/mL (180.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4436 mL 7.2179 mL 14.4358 mL
5 mM 0.2887 mL 1.4436 mL 2.8872 mL
10 mM 0.1444 mL 0.7218 mL 1.4436 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (144.36 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.29%

COA (255 KB) HNMR (302 KB) RP-HPLC (209 KB) MS (69 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4436 mL 7.2179 mL 14.4358 mL 36.0896 mL
5 mM 0.2887 mL 1.4436 mL 2.8872 mL 7.2179 mL
10 mM 0.1444 mL 0.7218 mL 1.4436 mL 3.6090 mL
15 mM 0.0962 mL 0.4812 mL 0.9624 mL 2.4060 mL
20 mM 0.0722 mL 0.3609 mL 0.7218 mL 1.8045 mL
25 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.4436 mL
30 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2030 mL
40 mM 0.0361 mL 0.1804 mL 0.3609 mL 0.9022 mL
50 mM 0.0289 mL 0.1444 mL 0.2887 mL 0.7218 mL
60 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6015 mL
80 mM 0.0180 mL 0.0902 mL 0.1804 mL 0.4511 mL
100 mM 0.0144 mL 0.0722 mL 0.1444 mL 0.3609 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sisomicin sulfate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sisomicin53179-09-2BacterialAntibioticInhibitorinhibitorinhibit

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