2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CCR

CCR

CC chemokine receptor

CCR

Related Products

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CCR (Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called achemokine. There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Specific chemokine receptors provide the portals for HIV to get into cells, and others contribute to inflammatory diseases and cancer.

CCR Isoform Specific Products:

CCR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P991942A
    Lanerkitug (FUT8-KO)
    		Inhibitor
    Lanerkitug (FUT8-KO) (BAY3375968 (FUT8-KO)) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Lanerkitug (HY-P991942) selectively depletes human CCR8+Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors.
    Lanerkitug (FUT8-KO)
  • HY-RS02169
    CCR8 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR8 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR8 Human Pre-designed siRNA Set A
  • HY-173516
    CCR5-IN-1
    		Inhibitor
    CCR5-IN-1 (compound 3ad) is a selective allosteric CCR5 inhibitor with an IC50 of 1.09 μM. CCR5-IN-1 can be used in the study of cardiovascular, central nervous system, immune system, and infectious diseases.
    CCR5-IN-1
  • HY-P992334
    CM369
    		Inhibitor
    CM369 is a humanized monoclonal antibody against CCR8 that possesses potential immunomodulatory and anti-tumor activities. CM369 can be used in cancer research.
    CM369
  • HY-P991135
    Enzelkitug
    		Inhibitor
    Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies.
    Enzelkitug
  • HY-120406
    PLS-123
    		Inhibitor
    LPS-123 is a covalently irreversible BTK inhibitor with an IC50 of < 5 nM. LPS-123 simultaneously inhibits the catalytic activity of BTK at Tyr551 and its self-activation at Tyr223. LPS-123 inhibits phosphorylation of the AKT/mTOR and MAPK signaling pathways, activation of PLCγ2, ERK1/2, p38, AKT, and mTOR, and blocks the production of CCL3 and CCL4 chemokines. LPS-123 exhibits significant anti-proliferative activity against various B-cell lymphoma cell lines and effectively induces apoptosis via a caspase-dependent pathway. LPS-123 also demonstrates significant antitumor activity in the OCI-Ly7 xenograft model. LPS-123 can be used for lymphoma research.
    PLS-123
  • HY-RS02148
    Ccr1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr1 Mouse Pre-designed siRNA Set A
  • HY-159927
    TAK-661
    		Inhibitor
    TAK-661 is a inhibitor of eosinophil chemotaxis. TAK-661 significantly reduces the bronchoconstriction during the late phase, along with the inhibition of eosinophilia in bronchoalveolar lavage (BAL) and the eosinophil infiltration into the airway wall.
    TAK-661
  • HY-RS02173
    Ccr9 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr9 Mouse Pre-designed siRNA Set A
  • HY-15571A
    VCH-286
    		Inhibitor
    VCH-286 is a CCR5 inhibitor that exhibits potent in vitro anti-HIV-1 activity when used alone.
    VCH-286
  • HY-124848
    CMPD167
    		Inhibitor
    CMPD167 (MRK-1) is an orally active CCR5 inhibitor with potent antiviral activity in vitro.
    CMPD167
  • HY-P991944A
    ZL-1218 (FUT8-KO)
    		Inhibitor
    ZL-1218 (FUT8-KO) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the antibody-dependent cellular cytotoxicity (ADCC) effect of the antibody. ZL-1218 (FUT8-KO) can be used for the research of solid tumour.
    ZL-1218 (FUT8-KO)
  • HY-P991843
    Anti-CCR5 Antibody (HEK/1/85a/7a)
    		Inhibitor
    Anti-CCR5 Antibody (HEK/1/85a/7a) recognizes an epitope on human CCR5. CCR5 is a seven-transmembrane G-protein-coupled receptor (GPCR). Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-CCR5 Antibody (HEK/1/85a/7a)
  • HY-P3418A
    CKLF1-C27 TFA
    		Inhibitor
    CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research.
    CKLF1-C27 TFA
  • HY-19009B
    Propagermanium
    		Inhibitor
    Propagermanium is an orally active and selective CCR2 inhibitor. Propagermanium enhances IFN-γ, IL-2, 2',5'-oligoadenylate synthetase, and unspecified cytokine production, and induces mature cytolytic NK cell subsets. Propagermanium reduces HBe antigen and HBV DNA polymerase levels, promotes HBV clearance and lowers serum ALT. Propagermanium downregulates STAT1, inhibits pro-inflammatory microglia polarization, pro-inflammatory cytokine release, and monocyte/macrophage infiltration. Propagermanium can be used for the research of chronic hepatitis B, atherosclerosis, breast cancer, non-alcoholic steatohepatitis, insulin resistance, refractory gastric cancer, multiple myeloma, type 2 diabetes.
    Propagermanium
  • HY-RS02164
    Ccr6 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr6 Mouse Pre-designed siRNA Set A
  • HY-149087
    MR2938
    		Inhibitor
    MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research.
    MR2938
  • HY-RS02156
    Ccr3 Rat Pre-designed siRNA Set A
    		Inhibitor

    Ccr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr3 Rat Pre-designed siRNA Set A
  • HY-RS02170
    Ccr8 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr8 Mouse Pre-designed siRNA Set A
  • HY-RS02166
    CCR7 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR7 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR7 Human Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CCR Isoform Comparison

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