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Cat. No.: HY-P991944A

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ZL-1218 (FUT8-KO)

ZL-1218 (FUT8-KO) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the antibody-dependent cellular cytotoxicity (ADCC) effect of the antibody. ZL-1218 (FUT8-KO) can be used for the research of solid tumour.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

ZL-1218 (FUT8-KO) Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Biological Activity

Description

IC₅₀ & Target^[1]

CCR8

All CCR Isoforms :

In Vitro

ZL-1218 (HY-P991944) is a selective humanized IgG1 antibody, targeting CCR8. ZL-1218 induces antibody-dependent cellular cytotoxicity (ADCC), leading to NK cell-mediated depletion of CCR8-expressing regulatory T cells (Tregs). ZL-1218 blocks the binding of the CCR8 ligand CCL1 to CCR8 and reduces Treg recruitment by inhibiting the chemotaxis of CCR8+ cells. ZL-1218 reduces intratumoral Treg levels in a dose-dependent manner. ZL-1218 exerts enhanced antitumor activity when combined with the anti-PD-1 antibody. ZL-1218 can be used for solid tumour research^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Jing Zhang, et al. Abstract 3590: ZL-1218, a novel anti-CCR8 antibody, exerts potent antitumor effect by depleting intratumoral regulatory T cells. Cancer Res (2022) 82 (12_Supplement): 3590.

[2]. Jing Zhang, et al. 1399 ZL 1218 targets the most suppressive intratumoral Treg subpopulation to avoid peripheral toxicities. Journal for Immuno Therapy of Cancer. 7 November 2022 Volume 10,Issue Suppl

[3]. Elena Garralda;et al. Abstract CT162: Trial in progress: A phase I, open-label, multicenter study of ZL-1218, an anti-CCR8 IgG1, as a single agent and as combination therapy with anti-PD-1 antibody to evaluate the safety, tolerability, and pharmacokinetics in subjects with advanced solid tumor. Cancer Res (2024) 84 (7_Supplement): CT162.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
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- IC₅₀ & Target
- In Vitro
- Format
Chemical Information
Purity & Documentation
References

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ZL-1218 (FUT8-KO)

All CCR Isoforms