2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CM369

CM369 is a humanized monoclonal antibody against CCR8 that possesses potential immunomodulatory and anti-tumor activities. CM369 can be used in cancer research.

For research use only. We do not sell to patients.

CM369

CM369 Chemical Structure

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This product is a controlled substance and not for sale in your territory.

CM369 Related Antibodies

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

CM369 is a humanized monoclonal antibody against CCR8 that possesses potential immunomodulatory and anti-tumor activities. CM369 can be used in cancer research.

Species Reactivity

Human
IC50 & Target

CCR8

 

In Vitro

CM369 can bind to CCR8 on the surface of CCR8-positive tumor-infiltrating regulatory T cells within the tumor microenvironment and deplete these cells via antibody-dependent cell-mediated cytotoxicity (ADCC), thereby potentially reactivating the anti-tumor immune response.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CM369 Related Antibodies
Gene ID

1237  [NCBI]

Accession
Target

CCR8
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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CM369 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM369CM 369CM-369CCRCC chemokine receptorInhibitorinhibitorinhibit

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CM369
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HY-P992334
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