2. Signalwege
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. HDAC
  5. HDAC Isoform
  6. HDAC Inhibitor

HDAC Inhibitor

HDAC Inhibitors (319):

Art. -Nr. Produktname Wirkung Reinheit
  • HY-155699
    J27644
    		Inhibitor
    J27644 is a potent HDAC inhibitor. J27644 mitigates TGF-β-induced pulmonary fibrosis.
  • HY-141844
    HDAC/BET-IN-1
    		Inhibitor
    HDAC/BET-IN-1 displays submicromolar inhibitory activity against HDAC1 and 6 (IC50 = 0.163 μM and 0.067 μM), and BRD4 (Ki = 0.076 μM), and possess potent antileukemia activity.
  • HY-162906
    FLT3/HDAC-IN-2
    		Inhibitor
    FLT3/HDAC-IN-2 is (compound 25h) a FLT3/HDAC dual inhibitor. FLT3/HDAC-IN-2 has antiproliferative activity against MOLM-13 cells. FLT3/HDAC-IN-2 can be used in acute myeloid leukemia research.
  • HY-RS06073
    HDAC4 Human Pre-designed siRNA Set A
    		Inhibitor

    HDAC4 Human Pre-designed siRNA Set A contains three designed siRNAs for HDAC4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-159936
    CS4
    		Inhibitor
    CS4 is a selective HDAC inhibitor with the IC50 values of 38 nM, 12 nM, 5.8 μM, 19 μM and 61 μM against of HDAC1, HDAC6, HDAC8, HDAC4 and HDAC11, respectively. CS4 promotes α-tubulin and histone 3 acetylation. CS4 activates PPARγ and blocks glycolysis. CS4 induces cell cycle arrest at G2 phase and apoptosis, and shows anticancer effect both in vivo and in vitro.
  • HY-RS06074
    Hdac4 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Hdac4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-155397
    PRO-HD2
    		Inhibitor
    PRO-HD2 is a cell-specific, PROTAC-based HDAC6 degrader.
  • HY-W718894
    (R)-Dihydrolipoic acid
    		Inhibitor
    (R)-Dihydrolipoic acid is a compound that inhibits histone deacetylase 6 (HDAC6) activity. The structure of its complex with HDAC6 has been resolved. (R)-Dihydrolipoic acid can inhibit HDAC6 through specific interactions, providing a basis for understanding the relationship between HDAC function and oxidative stress.
  • HY-B0494R
    Bufexamac (Standard)
    		Inhibitor
    Bufexamac (Standard) is the analytical standard of Bufexamac. This product is intended for research and analytical applications. Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with Kds of 0.53 μM and 0.22 μM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug.
  • HY-10585S3
    Valproic acid-d4 sodium
    		Inhibitor
    Valproic acid-d4 (sodium) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
  • HY-168493
    FLT3/VEGFR2-IN-1
    		Inhibitor
    FLT3/VEGFR2-IN-1 (Compound 26) is a FLT3/VEGFR2/HDAC inhibitor with IC50 values of 14.5 nM, 3.9 nM, and 30.8 nM for FLT3, VEGFR2, and HDAC1, respectively. FLT3/VEGFR2-IN-1 can inhibit the phosphorylation of STAT3 and ERK1/2 and the proliferation of leukemia cells. FLT3/VEGFR2-IN-1 has anti-tumor activity and can be used for the research of acute myeloid leukemia.
  • HY-RS06079
    HDAC6 Human Pre-designed siRNA Set A
    		Inhibitor

    HDAC6 Human Pre-designed siRNA Set A contains three designed siRNAs for HDAC6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-139796
    ZYJ-34v
    		Inhibitor
    ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity.
  • HY-10221G
    Vorinostat (GMP)
    		Inhibitor
    Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available HDAC1, HDAC2, HDAC3 (Class I), HDAC6 and Inhibitors of HDAC7 (Class II) and Class IV (HDAC11).
  • HY-143325
    A2AAR/HDAC-IN-2
    		Inhibitor
    A2AAR/HDAC-IN-2 is a potent A2AAR/HDAC dual inhibitor, with good binding affinity for A2AAR (Ki=10.3 nM) and good inhibitory activity against HDAC1 (IC50=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor.
  • HY-178487
    anti-TNBC agent-12
    		Inhibitor
    anti-TNBC agent-12 (Compound 23a) is a multi-target antitumor agent targeting HDAC6 (IC50=30.3 nM), DNA, and inducing nitric oxide (NO) release. anti-TNBC agent-12 induces tumor cell apoptosis and G2/M phase cell cycle arrest. anti-TNBC agent-12 is promising for research of triple-negative breast cancer (TNBC).
  • HY-157401
    HDAC6-IN-29
    		Inhibitor
    HDAC6-IN-29 (compound 11g), hydroxamic analogue, is a HDAC6 inhibitor. HDAC6-IN-29 has potent antiproliferative activity against CAL-51 cells (IC50 = 1.17 μM) and is able to induce apoptosis and cause accumulation of cells in the S phase of the cell cycle. HDAC6-IN-29 can be used for the research of cancer.
  • HY-145688
    HDAC-IN-33
    		Inhibitor
    HDAC-IN-33 is a potent HDAC inhibitor with IC50s of 24, 46, and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 possesses potent antiproliferation activities against tumor cells. HDAC-IN-33 shows potent antitumor efficacy in vivo That trigger antitumor immunity.
  • HY-RS06089
    Hdac9 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Hdac9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-149371
    HDAC6-IN-16
    		Inhibitor
    HDAC6-IN-16 (compound 5c) is a histone deacetylase 6 (HDAC6) inhibitor, based on Quinazolin-4(3H)-One. HDAC6-IN-16 exhibits anticancer effect, inhibits colony-forming. And HDAC6-IN-16 arrests cell cycle at G2 phase and induces apoptosis.