HDAC/BET-IN-1
HDAC/BET-IN-1 displays submicromolar inhibitory activity against HDAC1 and 6 (IC50 = 0.163 μM and 0.067 μM), and BRD4 (Ki = 0.076 μM), and possess potent antileukemia activity.
For research use only. We do not sell to patients.
- CAS No.: 2757573-68-3
- Formula: C29H40N4O8S
- Molecular Weight:604.71
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HAL-01 | IC50 |
5.93 μM
Compound: 61
|
Anticancer activity against human HAL-01 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
Anticancer activity against human HAL-01 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
|
[PMID: 34582215] |
| HL-60 | IC50 |
2.75 μM
Compound: 61
|
Anticancer activity against human HL-60 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
|
[PMID: 34582215] |
| HPBALL | IC50 |
7.13 μM
Compound: 61
|
Anticancer activity against human HPBALL cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
Anticancer activity against human HPBALL cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
|
[PMID: 34582215] |
| K562 | IC50 |
5.99 μM
Compound: 61
|
Anticancer activity against human K562 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
Anticancer activity against human K562 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
|
[PMID: 34582215] |
| REH | IC50 |
7.79 μM
Compound: 61
|
Anticancer activity against human REH cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
Anticancer activity against human REH cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
|
[PMID: 34582215] |
| TALL-1 | IC50 |
2.93 μM
Compound: 61
|
Anticancer activity against human TALL-1 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
Anticancer activity against human TALL-1 cells assessed as cell growth inhibition by CellTiter-Glo luminescent assay
|
[PMID: 34582215] |
Chemical Information
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CAS No. 2757573-68-3
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Appearance Solid
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Molecular Weight 604.71
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Formula C29H40N4O8S
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Color White to off-white
-
SMILES
CC1=C2C(CCCCC2=C(N1)C(NC3=CC(S(N4CCOCC4)(=O)=O)=CC=C3OCCCCCCCC(NO)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)