2757573-68-3
2757573-68-3
Chemical Structure
HDAC/BET-IN-1
- CAS No.: 2757573-68-3
- Formula:C29H40N4O8S
- Molecular Weight:604.71
IUPAC Name: N-(2-((8-(hydroxyamino)-8-oxooctyl)oxy)-5-(morpholinosulfonyl)phenyl)-3-methyl-4-oxo-2,4,5,6,7,8-hexahydrocyclohepta[c]pyrrole-1-carboxamide
InChIKey: AWVPNUWHMBPXOU-UHFFFAOYSA-N
SMILES: CC1=C2C(CCCCC2=C(N1)C(NC3=CC(S(N4CCOCC4)(=O)=O)=CC=C3OCCCCCCCC(NO)=O)=O)=O
Biological Activity: HDAC/BET-IN-1 displays submicromolar inhibitory activity against HDAC1 and 6 (IC50 = 0.163 μM and 0.067 μM), and BRD4 (Ki = 0.076 μM), and possess potent antileukemia activity.
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HDAC/BET-IN-1 | HDAC/BET-IN-1 displays submicromolar inhibitory activity against HDAC1 and 6 (IC50 = 0.163 μM and 0.067 μM), and BRD4 (Ki = 0.076 μM), and possess potent antileukemia activity. | |||||||||||||||||||||
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Keywords
