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Cat. No.: HY-145688

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HDAC-IN-33

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HDAC-IN-33 is a potent HDAC inhibitor with IC₅₀s of 24, 46, and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 possesses potent antiproliferation activities against tumor cells. HDAC-IN-33 shows potent antitumor efficacy in vivo That trigger antitumor immunity.

For research use only. We do not sell to patients.

CAS No.: 2766688-19-9
Formula: C₂₁H₂₅N₃O₃
Molecular Weight:367.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

HDAC-IN-33 Chemical Structure

CAS No.: 2766688-19-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
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Bioz

Biological Activity

Description

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	3.97 μM Compound: 9l	Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
HEL	IC₅₀	0.36 μM Compound: 9l	Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
HepG2	IC₅₀	4.8 μM Compound: 9l	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
K562	IC₅₀	0.99 μM Compound: 9l	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
KG-1	IC₅₀	3.4 μM Compound: 9l	Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]
PC-3	IC₅₀	7.9 μM Compound: 9l	Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35152694]

In Vitro

HDAC-IN-33 (Compound 9l) shows good in vivo antitumor efficacies in both HEL xenograft model and murine melanoma model. HDAC-IN-33 promotes the antigen presentation and activate T cells, thereby triggering antitumor immunity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2766688-19-9
Molecular Weight 367.44
Formula C₂₁H₂₅N₃O₃
SMILES

O=C(NO)CCCCCCCOC1=CC=CC(C2=NC3=CC=CC=C3N2)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. "Chen C, et al. Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity. J Med Chem. 2022 Feb 24;65(4):3667-3683. " [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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HDAC-IN-33

Publications Citing Use of MedChemExpress (MCE) HDAC-IN-33

All HDAC Isoforms