ZYJ-34v
ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 1450662-32-4
- Formula: C27H35N3O6
- Molecular Weight:497.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ZYJ-34v can inhibit HDACs. The IC50 values of MDA-MB-231, HCT116, PC-3, HepG2 and MCF-7 cells were 1.41, 0.63 and 2.62, respectively. 4.23 and 4.76 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:1 μM
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Incubation Time:24 h
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Result:Inhibited deacetylation of tubulin, histone H3 and H4, and significantly induced an increase in the protein level of p21.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:a mouse MDA-MB-231 xenograft model[1]
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Dosage:90 mg/kg
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Administration:p.o.
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Result:Decreased the final tumor volume.
Chemical Information
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CAS No. 1450662-32-4
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Molecular Weight 497.58
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Formula C27H35N3O6
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SMILES
COC(C=C1)=CC=C1NC([C@H]2N(CC3=CC(OCC(NO)=O)=CC=C3C2)C(C(CCC)CCC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZYJ-34v Related Classifications
HY-139796 Related Classifications
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