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Art. -Nr.: HY-139796

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ZYJ-34v

ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1450662-32-4
Formel: C₂₇H₃₅N₃O₆
Molecular Weight:497.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ZYJ-34v Chemical Structure

CAS. Nr.: 1450662-32-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity^[1].

Alle HDAC Isoform-spezifische Produkte anzeigen :

In Vitro

ZYJ-34v can inhibit HDACs. The IC₅₀ values of MDA-MB-231, HCT116, PC-3, HepG2 and MCF-7 cells were 1.41, 0.63 and 2.62, respectively. 4.23 and 4.76 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231
Concentration:

1 μM
Incubation Time:

24 h
Result:

Inhibited deacetylation of tubulin, histone H3 and H4, and significantly induced an increase in the protein level of p21.

In Vivo

ZYJ-34v (90 mg/kg, orally, for 22 days) shows antitumor activity in MDA-MB-231 xenograft tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

a mouse MDA-MB-231 xenograft model^[1]
Dosage:

90 mg/kg
Administration:

p.o.
Result:

Decreased the final tumor volume.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

Chemical Information

CAS. Nr. 1450662-32-4
Molecular Weight 497.58
Formel C₂₇H₃₅N₃O₆
SMILES

COC(C=C1)=CC=C1NC([C@H]2N(CC3=CC(OCC(NO)=O)=CC=C3C2)C(C(CCC)CCC)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang Y, et al. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem Biol Drug Des. 2013 Aug;82(2):125-30. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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