ZYJ-34v
ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1450662-32-4
- 分子式: C27H35N3O6
- 分子量:497.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
ZYJ-34v can inhibit HDACs. The IC50 values of MDA-MB-231, HCT116, PC-3, HepG2 and MCF-7 cells were 1.41, 0.63 and 2.62, respectively. 4.23 and 4.76 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:MDA-MB-231
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Concentration:1 μM
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Incubation Time:24 h
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Result:Inhibited deacetylation of tubulin, histone H3 and H4, and significantly induced an increase in the protein level of p21.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:a mouse MDA-MB-231 xenograft model[1]
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Dosage:90 mg/kg
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Administration:p.o.
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Result:Decreased the final tumor volume.
化学情報
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CAS 番号 1450662-32-4
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分子量 497.58
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分子式 C27H35N3O6
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SMILES
COC(C=C1)=CC=C1NC([C@H]2N(CC3=CC(OCC(NO)=O)=CC=C3C2)C(C(CCC)CCC)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ZYJ-34v 関連分類
HY-139796 関連分類
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