1. Cell Cycle/DNA Damage
    Epigenetics
    Autophagy
    Anti-infection
    Stem Cell/Wnt
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. HDAC
    Autophagy
    Mitophagy
    HIV
    Notch
    Endogenous Metabolite
  3. Valproic acid-d4 sodium

Valproic acid-d4 sodium (Synonyms: VPA-d4 sodium; 2-Propylpentanoic Acid-d4 sodium)

Cat. No.: HY-10585S3
Handling Instructions

Valproic acid-d4 (VPA-d4) sodium is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

For research use only. We do not sell to patients.

Valproic acid-d4 sodium Chemical Structure

Valproic acid-d4 sodium Chemical Structure

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Description

Valproic acid-d4 (VPA-d4) sodium is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

170.22

Formula

C8H11D4NaO2

SMILES

CCC([2H])([2H])C(C([2H])([2H])CC)C(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Valproic acid-d4 sodium
Cat. No.:
HY-10585S3
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