Tigloidin  (Synonyms: Tigloyl pseudotropine; Tiglylpseudotropine; Tiglyssin)

Tigloidin is an analogue of atropine, with anticholinergic activity.

Tigloidine hydrobromide (20-60 mg/kg, i.p.) fails to protect the mice against the lethal effect of physostigmine, but at 100 mg/kg and above, it protects 80% of the animals against the lethal effect. Tigloidine markedly prevents tremor and salivation produced by tremorine at 80-100 mg/kg, but fails to prevent these effects in doses up to 40 mg/kg. Tigloidine (up to 100 mg/kg, i.p) does not significantly affects reserpine and tetrabenazine induced sedation and ptosis in mice. Tigloidine (25-50 mg/kg, i.p.) also fails to cause any behavioral changes in the cats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

223.31

C₁₃H₂₁NO₂

495-83-0

Liquid (Density: 1.06±0.1 g/cm³)

Light yellow to yellow

C/C=C(C)/C(O[C@H]1C[C@@H](N2C)CC[C@@H]2C1)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Sanghvi I, et al. Pharmacology of a potential anti-Parkinson agent: tigloidine. Eur J Pharmacol. 1968 Oct;4(3):246-53.  [Content Brief]