2. Others Apoptosis Anti-infection
  3. Fungal Environmental Pollutants Bacterial Antibiotic Apoptosis
  4. Triclosan

トリクロサン  (Synonyms: Triclosan)

製品番号: HY-B1119 純度: 99.98%
COA 取扱説明書 Technical Support

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.

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CAS 番号 : 3380-34-5

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10 mM * 1 mL in DMSO
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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Other Forms of Triclosan:

トリクロサン 関連抗体

Top Publications Citing Use of Products

    Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142.  [Abstract]

    RCS regression analysis between ASMI and cr-corrected Triclosan. Beta (solid lines) and 95% confidence levels (shaded areas).

    Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142.  [Abstract]

    Protein levels of IGF-1, p-Akt, and p-mTOR were lower in the muscle of Triclosan (0-50 μM, 48 h)-exposed mice than the chow group.

    Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142.  [Abstract]

    IHC staining revealed a lower IGF-1 level in the Triclosan-exposed group than in the chow group.

    Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942.  [Abstract]

    Our data showed that triclosan can stabilize KasA with a △Tm of 3.8℃ using nanoDSF.

    Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942.  [Abstract]

    Ratio of mean fluorescence 350/330 nm (1st derivative). KasA (10 μM) was tested in the presence of 100 μM of compounds. Sildenafil (purple) and triclosan (green) have a ΔTm of 6.7 and 3.8℃, respectively.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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    • カスタマーレビュー

    製品説明

    Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].

    Cellular Effect
    Cell Line Type Value Description References
    B-cell IC50
    20 μM
    Compound: Triclosan
    Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
    Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
    		[PMID: 19075064]
    HepG2 ED50
    2 μg/mL
    Compound: Triclosan
    Cytotoxicity against human HepG2 cells
    Cytotoxicity against human HepG2 cells
    		[PMID: 23092194]
    Vero CC50
    25 μM
    Compound: TCS
    Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation
    Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation
    		[PMID: 33636304]
    体外実験

    Triclosan (1-100 μM ; 24 h) decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Triclosan with 50 μM significantly increases cleaved caspase3 and Bax proteins and decreases Bcl-2[2].
    Triclosan (50 μM ; 1-3 h) induces the increased expressions of both phosphorylated p38 and JNK proteins[2].
    Triclosan (10-50 μM ; 3 h) with 50 μM decreases the GSH activity and increases the ROS generation to about 40% in cultured NSCs[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    トリクロサン 関連抗体

    Cell Viability Assay[2]

    Cell Line: Neural stem wells
    Concentration: 1, 10, 20, 30, 50 and 100 μM
    Incubation Time: 24 h
    Result: Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM.

    Western Blot Analysis[2]

    Cell Line: Neural stem wells
    Concentration: 50 μM
    Incubation Time: 1, 3 h
    Result: Did not affect the expressions of MAPK signaling proteins per se.
    Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins.
    体内実験

    Triclosan (5, 50, 500 mg/kg; oral gavage, five days a week for a total of four weeks) causes an increase in the production of anti-Der f IgE, IL-4, and IL-13[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Wild type BALB/cJ mice[3]
    Dosage: 5, 50, 500 mg/kg
    Administration: Oral gavage, five days a week for a total of four weeks
    Result: Caused an increase in the production of anti-dermatophagoides farinae (Der f) IgE, IL-4, and IL-13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen-exposed wild type mice.
    臨床実験
    分子量

    289.55

    分子式

    C12H7Cl3O2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 100 mg/mL (345.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Methanol : 100 mg/mL (345.36 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4536 mL 17.2682 mL 34.5364 mL
    5 mM 0.6907 mL 3.4536 mL 6.9073 mL
    10 mM 0.3454 mL 1.7268 mL 3.4536 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.98%

    COA (247 KB) HNMR (244 KB) RP-HPLC (245 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / Methanol 1 mM 3.4536 mL 17.2682 mL 34.5364 mL 86.3409 mL
    5 mM 0.6907 mL 3.4536 mL 6.9073 mL 17.2682 mL
    10 mM 0.3454 mL 1.7268 mL 3.4536 mL 8.6341 mL
    15 mM 0.2302 mL 1.1512 mL 2.3024 mL 5.7561 mL
    20 mM 0.1727 mL 0.8634 mL 1.7268 mL 4.3170 mL
    25 mM 0.1381 mL 0.6907 mL 1.3815 mL 3.4536 mL
    30 mM 0.1151 mL 0.5756 mL 1.1512 mL 2.8780 mL
    40 mM 0.0863 mL 0.4317 mL 0.8634 mL 2.1585 mL
    50 mM 0.0691 mL 0.3454 mL 0.6907 mL 1.7268 mL
    60 mM 0.0576 mL 0.2878 mL 0.5756 mL 1.4390 mL
    80 mM 0.0432 mL 0.2159 mL 0.4317 mL 1.0793 mL
    100 mM 0.0345 mL 0.1727 mL 0.3454 mL 0.8634 mL
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    Triclosan Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Triclosan3380-34-5FungalEnvironmental PollutantsBacterialAntibioticApoptosisEnvironmental ContaminantsAntibacterialfatty acid synthesisenoyl-acyl carrier protein reductaseFabIFabIG93Vneural stem cellscolitiscolorectal tumorigenesisInhibitorinhibitorinhibit

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