Triclosan

Name: Triclosan
Brand: MedChemExpress
SKU: HY-B1119
Rating: 5.0 (9 reviews)

Cat. No.: HY-B1119 Purity: 99.98%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 3380-34-5

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 9 publication(s) in Google Scholar

Other Forms of Triclosan:

9 Publications Citing Use of MCE Triclosan

Bio/Physico-chemical Assay

IHC

: Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]; RCS regression analysis between ASMI and cr-corrected Triclosan. Beta (solid lines) and 95% confidence levels (shaded areas).

: Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]; Protein levels of IGF-1, p-Akt, and p-mTOR were lower in the muscle of Triclosan (0-50 μM, 48 h)-exposed mice than the chow group.

: Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]; IHC staining revealed a lower IGF-1 level in the Triclosan-exposed group than in the chow group.

: Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]; Our data showed that triclosan can stabilize KasA with a △Tm of 3.8℃ using nanoDSF.

: Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]; Ratio of mean fluorescence 350/330 nm (1st derivative). KasA (10 μM) was tested in the presence of 100 μM of compounds. Sildenafil (purple) and triclosan (green) have a ΔTm of 6.7 and 3.8℃, respectively.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
B-cell	IC₅₀	20 μM Compound: Triclosan	Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs	[PMID: 19075064]
HepG2	ED₅₀	2 μg/mL Compound: Triclosan	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 23092194]
Vero	CC₅₀	25 μM Compound: TCS	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation	[PMID: 33636304]

In Vitro

Triclosan (1-100 μM ; 24 h) decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Triclosan with 50 μM significantly increases cleaved caspase3 and Bax proteins and decreases Bcl-2^[2].
Triclosan (50 μM ; 1-3 h) induces the increased expressions of both phosphorylated p38 and JNK proteins^[2].
Triclosan (10-50 μM ; 3 h) with 50 μM decreases the GSH activity and increases the ROS generation to about 40% in cultured NSCs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Neural stem wells
Concentration:	1, 10, 20, 30, 50 and 100 μM
Incubation Time:	24 h
Result:	Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM.

Western Blot Analysis^[2]

Cell Line:	Neural stem wells
Concentration:	50 μM
Incubation Time:	1, 3 h
Result:	Did not affect the expressions of MAPK signaling proteins per se. Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins.

In Vivo

Triclosan (5, 50, 500 mg/kg; oral gavage, five days a week for a total of four weeks) causes an increase in the production of anti-Der f IgE, IL-4, and IL-13^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild type BALB/cJ mice^[3]
Dosage:	5, 50, 500 mg/kg
Administration:	Oral gavage, five days a week for a total of four weeks
Result:	Caused an increase in the production of anti-dermatophagoides farinae (Der f) IgE, IL-4, and IL-13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen-exposed wild type mice.

Clinical Trial

분자량

289.55

화학식

C₁₂H₇Cl₃O₂

CAS No.

3380-34-5

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (345.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 100 mg/mL (345.36 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4536 mL	17.2682 mL	34.5364 mL
5 mM	0.6907 mL	3.4536 mL	6.9073 mL
10 mM	0.3454 mL	1.7268 mL	3.4536 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.98%

Select Batch:

Data Sheet (278 KB) SDS (537 KB)

COA (247 KB) HNMR (244 KB) RP-HPLC (245 KB)

Handling Instructions (2659 KB)

References

[1]. R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4. [Content Brief]

[2]. Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107. [Content Brief]

[3]. Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Methanol	1 mM	3.4536 mL	17.2682 mL	34.5364 mL	86.3409 mL
	5 mM	0.6907 mL	3.4536 mL	6.9073 mL	17.2682 mL
	10 mM	0.3454 mL	1.7268 mL	3.4536 mL	8.6341 mL
	15 mM	0.2302 mL	1.1512 mL	2.3024 mL	5.7561 mL
	20 mM	0.1727 mL	0.8634 mL	1.7268 mL	4.3170 mL
	25 mM	0.1381 mL	0.6907 mL	1.3815 mL	3.4536 mL
	30 mM	0.1151 mL	0.5756 mL	1.1512 mL	2.8780 mL
	40 mM	0.0863 mL	0.4317 mL	0.8634 mL	2.1585 mL
	50 mM	0.0691 mL	0.3454 mL	0.6907 mL	1.7268 mL
	60 mM	0.0576 mL	0.2878 mL	0.5756 mL	1.4390 mL
	80 mM	0.0432 mL	0.2159 mL	0.4317 mL	1.0793 mL
	100 mM	0.0345 mL	0.1727 mL	0.3454 mL	0.8634 mL

Triclosan Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triclosan3380-34-5FungalEnvironmental PollutantsBacterialAntibioticApoptosisEnvironmental ContaminantsAntibacterialfatty acid synthesisenoyl-acyl carrier protein reductaseFabIFabIG93Vneural stem cellscolitiscolorectal tumorigenesisInhibitorinhibitorinhibit

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Triclosan

고객리뷰

Other Forms of Triclosan:

Triclosan Related Antibodies

9 Publications Citing Use of MCE Triclosan

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Triclosan Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Triclosan Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report